5-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylamino]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylamino]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester
• CAS No.: 106672-81-5
• Molecular Formula: C₂₀H₂₈N₄O₄
• Molecular Weight: 388.467
• Mol file: 106672-81-5.mol

Synonyms:5-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylamino]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

Chemical Property of 5-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylamino]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylamino]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester

There total 2 articles about 5-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylamino]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C20H30N4O4 (106672-77-9) → 5-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylamino]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester (106672-81-5)

Guidance literature:

With bromine; sodium acetate; In acetic acid; for 0.166667h; Ambient temperature;

DOI:10.1002/ardp.19863191207

Reference yield:

Hydrazincarboxamid → 5-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylamino]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester (106672-81-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 24 h / Ambient temperature

2: 80 percent / CH₃COONa, Br₂ / acetic acid / 0.17 h / Ambient temperature

With bromine; sodium acetate; In ethanol; acetic acid;

DOI:10.1002/ardp.19863191207

Reference yield: 40.0%

5-[3-(3-Piperidin-1-ylmethyl-phenoxy)-propylamino]-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester (106672-81-5) → N-<3-(3-Piperidinomethyl-phenoxy)propyl>-1,3,4-oxadiazol-2-amin

Guidance literature:

With hydrogenchloride; potassium hydroxide; 1.) room temp., 2.) heating, 15 min;

DOI:10.1002/ardp.19863191207

upstream raw materials:

C₂₀H₃₀N₄O₄