2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole

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Chemical Name:2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole
CAS No.:1227147-84-3
Molecular Formula:C₂₂H₁₈F₃N₃O₂
Molecular Weight:413.399
Hs Code.:

Synonyms:2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole

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Chemical Property of 2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole

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Technology Process of 2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole

There total 8 articles about 2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1227148-15-3
2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole

: 1227147-84-3
2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole

Guidance literature:: With manganese(IV) oxide; In tetrahydrofuran; for 5h; Reflux;

Reference yield:

: 2096-86-8
p-Tolylaceton

: 1227147-84-3
2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 6 h / 0 - 20 °C

2.1: acetic acid / 4 h / 90 °C

3.1: water; lithium hydroxide / ethanol / 1 h / 40 °C

3.2: 20 °C

4.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 16 h / 20 °C

5.1: Burgess Reagent / tetrahydrofuran / 1 h / 70 °C

6.1: manganese(IV) oxide / tetrahydrofuran / 5 h / Reflux

With manganese(IV) oxide; Burgess Reagent; water; acetic acid; HATU; lithium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 261952-24-3
2-amino-2-(4-(trifluoromethoxy)phenyl)acetic acid

: 1227147-84-3
2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride; sulfuric acid / tetrahydrofuran / 24 h / 20 °C

2.1: HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 16 h / 20 °C

3.1: Burgess Reagent / tetrahydrofuran / 1 h / 70 °C

4.1: manganese(IV) oxide / tetrahydrofuran / 5 h / Reflux

With manganese(IV) oxide; lithium borohydride; Burgess Reagent; sulfuric acid; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;