N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-L-alanine

Base Information

Chemical Name:N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-L-alanine
CAS No.:858104-02-6
Molecular Formula:C₂₈H₂₄F₂N₂O₆S
Molecular Weight:554.571
Hs Code.:

Synonyms:N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-L-alanine

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Chemical Property of N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-L-alanine

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Technology Process of N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-L-alanine

There total 9 articles about N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033750-47-8
C₃₂H₃₂F₂N₂O₆S

: 858104-02-6
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-L-alanine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 858104-48-0
(3R,4R)-1-(4-fluorophenyl)-3-[(3-nitropyridin-2-yl)dithio]-4-[4-(t-butoxycarbonylmethoxy)phenyl]azetidin-2-one

: 858104-02-6
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-L-alanine

Guidance literature:: Multi-step reaction with 6 steps

1.1: tributylphosphine; water / acetone / 0.5 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.1: 4-methyl-morpholine / dichloromethane / 0.17 h / 20 °C

3.2: 25 h

4.1: trifluoroacetic acid / dichloromethane / 1 h

5.1: 4-methyl-morpholine / dichloromethane / 0.08 h

5.2: 3 h

6.1: trifluoroacetic acid / dichloromethane / 2 h

With 4-methyl-morpholine; tributylphosphine; water; trifluoroacetic acid; In dichloromethane; acetone;

Reference yield:

: 858104-49-1
(3R,4R)-1-(4-fluorophenyl)-3-[(4-fluorobenzoyl)methylthio]-4-[4-(t-butoxycarbonylmethoxy)phenyl]azetidin-2-one

: 858104-02-6
N-{[4-((2R,3R)-1-(4-fluorophenyl)-3-{[2-(4-fluorophenyl)-2-oxoethyl]thio}-4-oxoazetidin-2-yl)phenoxy]acetyl}-L-alanine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2.1: 4-methyl-morpholine / dichloromethane / 0.17 h / 20 °C

2.2: 25 h

3.1: trifluoroacetic acid / dichloromethane / 1 h

4.1: 4-methyl-morpholine / dichloromethane / 0.08 h

4.2: 3 h

5.1: trifluoroacetic acid / dichloromethane / 2 h

With 4-methyl-morpholine; trifluoroacetic acid; In dichloromethane;