1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide

Base Information

Chemical Name:1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide
CAS No.:1303509-81-0
Molecular Formula:C₂₀H₂₄BrFN₄O₅S
Molecular Weight:531.403
Hs Code.:

1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide

Synonyms:1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide

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Chemical Property of 1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide

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Technology Process of 1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide

There total 8 articles about 1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1303510-18-0
7-(4-bromo-2-fluoro-phenylamino)-8-[1-(2,3-dihydroxy-propyl)-cyclopropanesulfonylamino]-6-methyl-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-carboxylic acid tert-butyl ester

: 1303509-81-0
1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide

Guidance literature:: 7-(4-bromo-2-fluoro-phenylamino)-8-[1-(2,3-dihydroxy-propyl)-cyclopropanesulfonylamino]-6-methyl-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In tetrahydrofuran; water; at 45 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1303510-05-5
trifluoro-methanesulfonic acid 1-benzyl-6-methyl-8-nitro-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-7-yl ester

: 1303509-81-0
1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 90 °C / Inert atmosphere

2: hydrogen bromide; acetic acid / 2 h / 20 °C

3: dmap / acetonitrile / 2 h / 20 °C

4: zinc; ammonium chloride / water; tetrahydrofuran / 0.67 h / 20 °C

5: pyridine / 12 h / 20 °C

6: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 12 h / 20 °C

7: hydrogenchloride / water; tetrahydrofuran / 1 h / 45 °C

With pyridine; hydrogenchloride; dmap; osmium(VIII) oxide; water; hydrogen bromide; ammonium chloride; caesium carbonate; acetic acid; 4-methylmorpholine N-oxide; zinc; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; water; toluene; acetonitrile;

Reference yield:

: 1303510-04-4
1-benzyl-7-hydroxy-6-methyl-8-nitro-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one

: 1303509-81-0
1-(2,3-dihydroxy-propyl)-cyclopropanesulfonic acid [7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-imidazo[1,2-a]pyridin-8-yl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dichloromethane / 4 h / -78 - 20 °C

2: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 90 °C / Inert atmosphere

3: hydrogen bromide; acetic acid / 2 h / 20 °C

4: dmap / acetonitrile / 2 h / 20 °C

5: zinc; ammonium chloride / water; tetrahydrofuran / 0.67 h / 20 °C

6: pyridine / 12 h / 20 °C

7: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 12 h / 20 °C

8: hydrogenchloride / water; tetrahydrofuran / 1 h / 45 °C

With pyridine; hydrogenchloride; dmap; osmium(VIII) oxide; water; hydrogen bromide; ammonium chloride; caesium carbonate; acetic acid; 4-methylmorpholine N-oxide; triethylamine; zinc; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;