2-((4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-6-((4-(ethyl(mtolyl)carbamoyl)benzyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid

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Chemical Name:2-((4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-6-((4-(ethyl(mtolyl)carbamoyl)benzyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid
CAS No.:1236265-29-4
Molecular Formula:C₃₃H₃₇N₇O₅
Molecular Weight:611.701
Hs Code.:

Synonyms:2-((4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-6-((4-(ethyl(mtolyl)carbamoyl)benzyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid

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Chemical Property of 2-((4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-6-((4-(ethyl(mtolyl)carbamoyl)benzyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid

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Technology Process of 2-((4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-6-((4-(ethyl(mtolyl)carbamoyl)benzyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid

There total 7 articles about 2-((4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-6-((4-(ethyl(mtolyl)carbamoyl)benzyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1236264-99-5
4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1236265-29-4
2-((4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-6-((4-(ethyl(mtolyl)carbamoyl)benzyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid

Guidance literature:: 4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide; glycine ethyl ester hydrochloride; With sodium hydroxide; In water; acetonitrile; at 80 ℃; pH=9 - 10;

With hydrogenchloride; In water; acetonitrile;

Reference yield:

: 2-(4,6-dichloro-1,3,5-triazin-2-yl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1236265-29-4
2-((4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-6-((4-(ethyl(mtolyl)carbamoyl)benzyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / acetonitrile; water / 20 °C / pH 9 - 10

2: sodium hydroxide / acetonitrile; water / 80 °C / pH 9 - 10

With sodium hydroxide; In water; acetonitrile;
DOI:10.1021/acsmedchemlett.5b00138

Reference yield:

: 33233-67-9
4-(tert-Butoxycarbonylaminomethyl)benzoic acid

: 1236265-29-4
2-((4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-6-((4-(ethyl(mtolyl)carbamoyl)benzyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Cooling with ice

2: dichloromethane / 0.33 h / 20 °C

3: sodium hydroxide / acetonitrile; water / 20 °C / pH 9 - 10

4: sodium hydroxide / acetonitrile; water / 80 °C / pH 9 - 10

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In dichloromethane; water; acetonitrile;
DOI:10.1021/acsmedchemlett.5b00138