Technology Process of (S)-2,6,6-Trimethyl-5-(2-methyl-benzyl)-cyclohex-2-enone
There total 5 articles about (S)-2,6,6-Trimethyl-5-(2-methyl-benzyl)-cyclohex-2-enone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3S,5S)-5-Isopropenyl-2,2,6-trimethyl-3-(2-methyl-benzyl)-cyclohexanone;
With
methanol; oxygen; ozone;
In
dichloromethane;
at -70 ℃;
With
dmap; acetic anhydride; triethylamine;
In
benzene;
for 4h;
Heating;
DOI:10.1055/s-2002-34902
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Li / tetrahydrofuran / 1 h
2.1: PCC; silica gel / CH2Cl2 / 6 h
3.1: Li; NH3 / tetrahydrofuran / 0.25 h
3.2: 55 percent / tetrahydrofuran / 1 h
4.1: 70 percent / LDA; HMPA / tetrahydrofuran / 24 h / 0 - 20 °C
5.1: O3/O2; MeOH / CH2Cl2 / -70 °C
5.2: 70 percent / Ac2O; Et3N; DMAP / benzene / 4 h / Heating
With
methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ammonia; oxygen; silica gel; lithium; ozone; pyridinium chlorochromate; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
1.1: Barbier reaction / 5.2: Criegee fragmentation;
DOI:10.1055/s-2002-34902
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: PCC; silica gel / CH2Cl2 / 6 h
2.1: Li; NH3 / tetrahydrofuran / 0.25 h
2.2: 55 percent / tetrahydrofuran / 1 h
3.1: 70 percent / LDA; HMPA / tetrahydrofuran / 24 h / 0 - 20 °C
4.1: O3/O2; MeOH / CH2Cl2 / -70 °C
4.2: 70 percent / Ac2O; Et3N; DMAP / benzene / 4 h / Heating
With
methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ammonia; oxygen; silica gel; lithium; ozone; pyridinium chlorochromate; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
4.2: Criegee fragmentation;
DOI:10.1055/s-2002-34902
