(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-(5-propylthiophen-3-yl)butan-2-yl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-(5-propylthiophen-3-yl)butan-2-yl)carbamate
CAS No.:1428650-48-9
Molecular Formula:C₂₄H₃₃NO₅S
Molecular Weight:447.596
Hs Code.:

Synonyms:(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-(5-propylthiophen-3-yl)butan-2-yl)carbamate

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Chemical Property of (R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-(5-propylthiophen-3-yl)butan-2-yl)carbamate

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Technology Process of (R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-(5-propylthiophen-3-yl)butan-2-yl)carbamate

There total 6 articles about (R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-(5-propylthiophen-3-yl)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 36155-79-0
4-bromo-2-propyl thiophene

: 1428650-45-6
(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-(methoxy(methyl)amino)-1-oxobutan-2-yl)carbamate

: 1428650-48-9
(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-(5-propylthiophen-3-yl)butan-2-yl)carbamate

Guidance literature:: 4-bromo-2-propyl thiophene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.666667h; Inert atmosphere;

(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-(methoxy(methyl)amino)-1-oxobutan-2-yl)carbamate; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetasy.2013.02.003

Reference yield:

: 1428650-47-8
(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-hydroxybutan-2-yl)carbamate

: 1428650-48-9
(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-(5-propylthiophen-3-yl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: [bis(acetoxy)iodo]benzene; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; water / 14 h / 20 °C / Inert atmosphere

2.1: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane / 0.25 h / -15 °C / Inert atmosphere

2.2: 2 h / -10 - 20 °C / Inert atmosphere

3.1: n-butyllithium / diethyl ether; hexane / 0.67 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

With 4-methyl-morpholine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; n-butyllithium; [bis(acetoxy)iodo]benzene; isobutyl chloroformate; In diethyl ether; hexane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tetasy.2013.02.003

Reference yield:

: 1260604-96-3
(R)-2-((tert-butoxycarbonyl)amino)-4-(3,4-dimethoxyphenyl)butanoic acid

: 1428650-48-9
(R)-tert-butyl (4-(3,4-dimethoxyphenyl)-1-oxo-1-(5-propylthiophen-3-yl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane / 0.25 h / -15 °C / Inert atmosphere

1.2: 2 h / -10 - 20 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 0.67 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

With 4-methyl-morpholine; n-butyllithium; isobutyl chloroformate; In diethyl ether; hexane; dichloromethane;
DOI:10.1016/j.tetasy.2013.02.003