(2-chloromethyl-6-fluoro-quinazolin-4-yl)-(4-methoxy-phenyl)methylamine

Base Information

• Chemical Name: (2-chloromethyl-6-fluoro-quinazolin-4-yl)-(4-methoxy-phenyl)methylamine
• CAS No.: 1216816-12-4
• Molecular Formula: C₁₇H₁₅ClFN₃O
• Molecular Weight: 331.777
• Mol file: 1216816-12-4.mol

Synonyms:(2-chloromethyl-6-fluoro-quinazolin-4-yl)-(4-methoxy-phenyl)methylamine

Chemical Property of (2-chloromethyl-6-fluoro-quinazolin-4-yl)-(4-methoxy-phenyl)methylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2-chloromethyl-6-fluoro-quinazolin-4-yl)-(4-methoxy-phenyl)methylamine

There total 1 articles about (2-chloromethyl-6-fluoro-quinazolin-4-yl)-(4-methoxy-phenyl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-chloro-2-(chloromethyl)-6-fluoroquinazoline (147003-97-2) + N-methyl-N-(4-methoxyphenyl)amine (5961-59-1) → (2-chloromethyl-6-fluoro-quinazolin-4-yl)-(4-methoxy-phenyl)methylamine (1216816-12-4)

Guidance literature:

4-chloro-2-(chloromethyl)-6-fluoroquinazoline; N-methyl-N-(4-methoxyphenyl)amine; With hydrogenchloride; In isopropyl alcohol; at 20 ℃;

With sodium hydroxide; In dichloromethane; water; isopropyl alcohol;

Reference yield:

(2-chloromethyl-6-fluoro-quinazolin-4-yl)-(4-methoxy-phenyl)methylamine (1216816-12-4) + potassium phtalimide (1074-82-4) → C25H19FN4O3

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 0.166667h;

upstream raw materials:

4-chloro-2-(chloromethyl)-6-fluoroquinazoline

N-methyl-N-(4-methoxyphenyl)amine