(R)-N-(1-phenyl-2-piperidinoethyl)-2-(2-dimethylaminoethyloxy)acetamide

Base Information

Chemical Name:(R)-N-(1-phenyl-2-piperidinoethyl)-2-(2-dimethylaminoethyloxy)acetamide
CAS No.:157303-83-8
Molecular Formula:C₁₉H₃₁N₃O₂
Molecular Weight:333.474
Hs Code.:

Synonyms:(R)-N-(1-phenyl-2-piperidinoethyl)-2-(2-dimethylaminoethyloxy)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(1-phenyl-2-piperidinoethyl)-2-(2-dimethylaminoethyloxy)acetamide

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Technology Process of (R)-N-(1-phenyl-2-piperidinoethyl)-2-(2-dimethylaminoethyloxy)acetamide

There total 5 articles about (R)-N-(1-phenyl-2-piperidinoethyl)-2-(2-dimethylaminoethyloxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 98278-28-5
<2-(dimethylamino)ethoxy>acetic acid

: 142950-82-1
(R)-(-)-1-(2-amino-2-phenylethyl)piperidine

: 157303-83-8
(R)-N-(1-phenyl-2-piperidinoethyl)-2-(2-dimethylaminoethyloxy)acetamide

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.1248/cpb.42.690

Reference yield:

: 110-89-4
piperidine

: 157303-83-8
(R)-N-(1-phenyl-2-piperidinoethyl)-2-(2-dimethylaminoethyloxy)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / Et₃N, diethylphosphorocyanidate / dimethylformamide / 25 h / Ambient temperature

2: 100 percent / 33percent HBr/AcOH / Ambient temperature

3: LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: 90 percent / Et₃N, diethylphosphorocyanidate / dimethylformamide / 12 h / Ambient temperature

With lithium aluminium tetrahydride; diethyl cyanophosphonate; hydrogen bromide; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.690

Reference yield:

: 17609-52-8
Z-D-phenylglycine

: 157303-83-8
(R)-N-(1-phenyl-2-piperidinoethyl)-2-(2-dimethylaminoethyloxy)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / Et₃N, diethylphosphorocyanidate / dimethylformamide / 25 h / Ambient temperature

2: 100 percent / 33percent HBr/AcOH / Ambient temperature

3: LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: 90 percent / Et₃N, diethylphosphorocyanidate / dimethylformamide / 12 h / Ambient temperature

With lithium aluminium tetrahydride; diethyl cyanophosphonate; hydrogen bromide; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.690