tert-butyl 4-(4-(4-(2-(1-amino-1-oxopropan-2-yl)phenethyl)-5-chloropyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(4-(2-(1-amino-1-oxopropan-2-yl)phenethyl)-5-chloropyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS No.:1566543-99-4
Molecular Formula:C₂₈H₃₆ClN₇O₃
Molecular Weight:554.092
Hs Code.:

Synonyms:tert-butyl 4-(4-(4-(2-(1-amino-1-oxopropan-2-yl)phenethyl)-5-chloropyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(4-(2-(1-amino-1-oxopropan-2-yl)phenethyl)-5-chloropyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(4-(2-(1-amino-1-oxopropan-2-yl)phenethyl)-5-chloropyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(4-(4-(2-(1-amino-1-oxopropan-2-yl)phenethyl)-5-chloropyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1029413-55-5
4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester

: 1566543-96-1
2-(2-(2-(2,5-dichloropyrimidin-4-yl)ethyl)phenyl)propanamide

: 1566543-99-4
tert-butyl 4-(4-(4-(2-(1-amino-1-oxopropan-2-yl)phenethyl)-5-chloropyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: With acetic acid; In butan-1-ol; at 150 ℃; for 0.5h;

Reference yield:

: 615256-95-6
2-iodo-2-phenylacetic acid

: 1566543-99-4
tert-butyl 4-(4-(4-(2-(1-amino-1-oxopropan-2-yl)phenethyl)-5-chloropyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 2 h / 40 °C

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 5 h / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h

4.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 1,4-dioxane / 2.5 h / 60 °C / Inert atmosphere

5.1: hydrogen; platinum(IV) oxide / N,N-dimethyl-formamide; methanol / 120 h / 20 °C

6.1: acetic acid / butan-1-ol / 0.5 h / 150 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1566543-63-2
2-(2-iodophenyl)propionamide

: 1566543-99-4
tert-butyl 4-(4-(4-(2-(1-amino-1-oxopropan-2-yl)phenethyl)-5-chloropyrimidin-2-ylamino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

1.2: 5 h / 60 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h

3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 1,4-dioxane / 2.5 h / 60 °C / Inert atmosphere

4.1: hydrogen; platinum(IV) oxide / N,N-dimethyl-formamide; methanol / 120 h / 20 °C

5.1: acetic acid / butan-1-ol / 0.5 h / 150 °C

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; butan-1-ol;