Technology Process of (S)-N-{5-[(7-(2,3-dihydroxypropoxy)-5-oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-2-yl)amino]-2-fluorophenyl}benzamide
There total 5 articles about (S)-N-{5-[(7-(2,3-dihydroxypropoxy)-5-oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-2-yl)amino]-2-fluorophenyl}benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol; water;
for 3h;
Inert atmosphere;
Reflux;
DOI:10.1021/jm301539x
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
2: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / ethyl acetate
4: palladium diacetate; XPhos; potassium tert-butylate / toluene; tert-butyl alcohol / 3 h / Inert atmosphere; Reflux
5: toluene-4-sulfonic acid / methanol; water / 3 h / Inert atmosphere; Reflux
With
oxalyl dichloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; palladium diacetate; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; XPhos;
In
tetrahydrofuran; methanol; water; ethyl acetate; toluene; tert-butyl alcohol;
4: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm301539x
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate
2: palladium diacetate; XPhos; potassium tert-butylate / toluene; tert-butyl alcohol / 3 h / Inert atmosphere; Reflux
3: toluene-4-sulfonic acid / methanol; water / 3 h / Inert atmosphere; Reflux
With
palladium 10% on activated carbon; potassium tert-butylate; hydrogen; palladium diacetate; toluene-4-sulfonic acid; XPhos;
In
methanol; water; ethyl acetate; toluene; tert-butyl alcohol;
2: |Buchwald-Hartwig Coupling;
DOI:10.1021/jm301539x
