2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)benzenamine

Base Information

• Chemical Name: 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)benzenamine
• CAS No.: 1451391-22-2
• Molecular Formula: C₁₃H₁₇BF₃NO₃
• Molecular Weight: 303.089
• Mol file: 1451391-22-2.mol

Synonyms:2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)aniline

Chemical Property of 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)benzenamine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)benzenamine ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)benzenamine

There total 2 articles about 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) + 2-bromo-4-trifluoromethoxyaniline (175278-17-8) → 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)aniline (1451391-22-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In 1,4-dioxane; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jacs.9b13599 DOI:10.1021/acs.orglett.0c03497

Reference yield:

→ 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)aniline (1451391-22-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 95 ℃; for 8h; Inert atmosphere;

Reference yield: 91.0%

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)aniline (1451391-22-2) + 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl trifluoromethanesulfonate (137058-15-2) → 5-(trifluoromethoxy)-3',4',5',6'-tetrahydro[1,1':2',1''-terphenyl]-2-amine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jacs.9b13599

upstream raw materials:

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

2-bromo-4-trifluoromethoxyaniline

Downstream raw materials:

2-azido-5-trifluoromethoxyphenylboronic acid pinacolate ester

C₁₇H₁₉F₃N₄O₃

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