(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[⁽¹³⁾C₆]phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride

Base Information

• Chemical Name: (4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[⁽¹³⁾C₆]phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride
• CAS No.: 1307233-70-0
• Molecular Formula: C₂₂H₂₁N₇O₂*ClH
• Molecular Weight: 457.849

Synonyms:(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[⁽¹³⁾C₆]phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride

Chemical Property of (4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[⁽¹³⁾C₆]phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride

Chemical Property:

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Technology Process of (4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[⁽¹³⁾C₆]phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride

There total 10 articles about (4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[⁽¹³⁾C₆]phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-3-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-amine (1307233-74-4) + (4-methylpiperazin-1-yl)-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[(13)C6]phenyl]methanone (1307233-80-2) → (4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[(13)C6]phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride (1307233-70-0)

Guidance literature:

With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; at 130 ℃; for 0.666667h; Inert atmosphere; Microwave irradiation;

Reference yield:

(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[(13)C6]phenyl)(4-methylpiperazin-1-yl)methanone (1307233-71-1) → (4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[(13)C6]phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride (1307233-70-0)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; dichloromethane; for 1h;

Reference yield:

3-aminopyridin-4-ol (6320-39-4) → (4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)[(13)C6]phenyl)(4-methylpiperazin-1-yl)methanone hydrochloride (1307233-70-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3: N-Bromosuccinimide / acetic acid / 20 °C

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 0.67 h / 130 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; hexachloroethane; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

1-methyl-piperazine

3-aminopyrazinoic acid

3-amino-6-bromo-pyrazine-2-carboxylic acid

3-aminopyridin-4-ol

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