methyl (4-(2-(1,1-diphenylethylthio)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

Base Information

Chemical Name:methyl (4-(2-(1,1-diphenylethylthio)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate
CAS No.:258532-38-6
Molecular Formula:C₂₇H₂₇NO₅S
Molecular Weight:477.581
Hs Code.:

Synonyms:methyl (4-(2-(1,1-diphenylethylthio)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

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Chemical Property of methyl (4-(2-(1,1-diphenylethylthio)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

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Technology Process of methyl (4-(2-(1,1-diphenylethylthio)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

There total 8 articles about methyl (4-(2-(1,1-diphenylethylthio)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 258532-80-8
methyl (4-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

: 74630-84-5
1,1-diphenylethane-1-thiol

: 258532-38-6
methyl (4-(2-(1,1-diphenylethylthio)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

Guidance literature:

Reference yield:

: [4-(2-methanesulfonyloxy-ethyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yloxy]-acetic acid methyl ester

: 74630-84-5
1,1-diphenylethane-1-thiol

: 258532-38-6
methyl (4-(2-(1,1-diphenylethylthio)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2005.10.050

Reference yield:

: 258532-76-2
8-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

: 258532-38-6
methyl (4-(2-(1,1-diphenylethylthio)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / pyridinium p-toluenesulfonate / dimethylformamide / 18 h / 20 °C

2: sodium hydride / dimethylformamide / 17.5 h / 20 °C

3: 415 mg / p-toluenesulfonic acid hydrate / methanol / 2 h / 20 °C

4: 97 percent / K₂CO₃ / dimethylformamide / 20 °C

5: Et₃N / CH₂Cl₂ / cooling

6: 172.5 mg / sodium hydride / dimethylformamide / 20 °C

With pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.050