3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

Base Information

• Chemical Name: 3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
• CAS No.: 1241889-89-3
• Molecular Formula: C₂₅H₂₇FN₂O
• Molecular Weight: 390.501

Synonyms:3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

Chemical Property of 3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

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Technology Process of 3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

There total 1 articles about 3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine (64169-39-7) + 3-Aminophenylboronic acid (30418-59-8,280563-63-5) → 3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine (1241889-89-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 70 - 80 ℃; Inert atmosphere;

DOI:10.1021/jm1005034

Reference yield: 92.0%

3-phthalimidopropionyl chloride (17137-11-0) + 3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine (1241889-89-3) → N-(3-(1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl)phenyl)-3-(1,3-dioxoisoindolin-2-yl)propanamide (1416149-72-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2012.10.089

Reference yield:

3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine (1241889-89-3) + oxalic acid (144-62-7,97993-78-7) → 3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine oxalate (1241890-07-2)

Guidance literature:

In acetone;

DOI:10.1021/jm1005034

upstream raw materials:

3-(5-bromo-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

3-Aminophenylboronic acid

Downstream raw materials:

3-(5-(3-amino-phenyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine oxalate

N-(3-(1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl)phenyl)-3-(1,3-dioxoisoindolin-2-yl)propanamide

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