Z-PRO-LEU-ALA-NHOH

Base Information

• Chemical Name: Z-PRO-LEU-ALA-NHOH
• CAS No.: 123984-00-9
• Molecular Formula: C₂₂H₃₂N₄O₆
• Molecular Weight: 448.519
• Hs Code.: 3507909090
• Mol file: 123984-00-9.mol

Synonyms:Z-PRO-LEU-ALA-NHOH

Chemical Property of Z-PRO-LEU-ALA-NHOH

Chemical Property:

• PSA: 137.07000
• LogP: 2.43920
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

z-Pro-Leu-Ala-NHOH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: z-Pro-Leu-Ala-NHOH is an inhibitor of interstitial collagenase and human matrix metalloproteinases.

Technology Process of Z-PRO-LEU-ALA-NHOH

There total 14 articles about Z-PRO-LEU-ALA-NHOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ Z-Pro-Leu-Ala-NHOH (123984-00-9)

Guidance literature:

Reference yield: 70.0%

benzyloxycarbonyl azide (3422-03-5) + HCl*Pro-Leu-Ala-NHOH (123984-21-4) → Z-Pro-Leu-Ala-NHOH (123984-00-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; a.) -70 deg C to -10 deg C; b.) 4 deg C;

DOI:10.1248/cpb.38.1007

Reference yield: 35.0%

benzyloxycarbonyl azide (3422-03-5) + (S)-Pyrrolidine-2-carboxylic acid [1-((S)-1-hydroxycarbamoyl-ethylcarbamoyl)-3-methyl-butyl]-amide; hydrochloride (123984-21-4) → (S)-2-[1-((S)-1-Hydroxycarbamoyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester (123984-00-9,123984-07-6,123984-15-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; a.) -70 deg C to -10 deg C; b.) 4 deg C;

DOI:10.1248/cpb.38.1007

upstream raw materials:

benzyloxycarbonyl azide

HCl*Pro-Leu-Ala-NHOH

1-(tert-butoxycarbonyl)-L-proline

N-tert-butoxycarbonyl-L-leucine

Refernces

• 1、 Odake,Okayama,Obata,Morikawa,Hattori,Hori,Nagai. "Vertebrate collagenase inhibitor. I. Tripeptidyl hydroxamic acids". . p. 1007 - 1011. Retrieved 2007/10/02.