Technology Process of 4-(tert-butyl-diphenyl-silanyloxy)-2-[1-(2-methoxymethoxy-ethyl)-allyl]-5-methyl-phenol
There total 5 articles about 4-(tert-butyl-diphenyl-silanyloxy)-2-[1-(2-methoxymethoxy-ethyl)-allyl]-5-methyl-phenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1.1: 95 percent / iPr2NEt / 18 h / 20 °C
2.1: 96 percent / LiAlH4 / tetrahydrofuran / 0.17 h / 20 °C
3.1: o-nitrophenyl selenocyanate; n-Bu3P / tetrahydrofuran / 0.25 h / 20 °C
3.2: 91 percent / H2O2 / tetrahydrofuran / 3.5 h / 20 °C
4.1: (NH4)2Ce(NO3)6 / acetonitrile; H2O / 0.33 h / 20 °C
4.2: 95 percent / Na2S2O4 / tetrahydrofuran; H2O / 0.17 h / 20 °C
5.1: 80 percent / imidazole; 4-DMAP / CH2Cl2 / 1 h / 20 °C
With
1H-imidazole; dmap; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; ammonium cerium(IV) nitrate; tributylphosphine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tetlet.2003.09.086
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 24 percent / immobilized lipase PS on diatomite / diethyl ether / 13 h / 20 °C
2.1: 95 percent / iPr2NEt / 18 h / 20 °C
3.1: 96 percent / LiAlH4 / tetrahydrofuran / 0.17 h / 20 °C
4.1: o-nitrophenyl selenocyanate; n-Bu3P / tetrahydrofuran / 0.25 h / 20 °C
4.2: 91 percent / H2O2 / tetrahydrofuran / 3.5 h / 20 °C
5.1: (NH4)2Ce(NO3)6 / acetonitrile; H2O / 0.33 h / 20 °C
5.2: 95 percent / Na2S2O4 / tetrahydrofuran; H2O / 0.17 h / 20 °C
6.1: 80 percent / imidazole; 4-DMAP / CH2Cl2 / 1 h / 20 °C
With
1H-imidazole; dmap; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; ammonium cerium(IV) nitrate; tributylphosphine; immobilized lipase PS on diatomite; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tetlet.2003.09.086
