1H-Pyrazole-3-carboxylicacid,5-amino-

Base Information

• Chemical Name: 1H-Pyrazole-3-carboxylicacid,5-amino-
• CAS No.: 124004-31-5
• Molecular Formula: C₄H₅N₃O₂
• Molecular Weight: 127.103
• Hs Code.: 2933199090
• Mol file: 124004-31-5.mol

Synonyms:5-Amino-1H-pyrazole-3-carboxylic acid;3-Carboxy-5-aminopyrazole;

Chemical Property of 1H-Pyrazole-3-carboxylicacid,5-amino-

Chemical Property:

• Vapor Pressure: 1.98E-13mmHg at 25°C
• Melting Point: 245-246 °C(Solv: water (7732-18-5))
• Refractive Index: 1.72
• Boiling Point: 561.2 °C at 760 mmHg
• PKA: 16.08±0.10(Predicted)
• Flash Point: 293.2 °C
• PSA: 92.00000
• Density: 1.677 g/cm³
• LogP: 0.27130
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-1H-pyrazole-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-3-carboxylicacid,5-amino-

There total 5 articles about 1H-Pyrazole-3-carboxylicacid,5-amino- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-nitro-1H-pyrazole-5-carboxylic acid → 5-amino-1H-pyrazole-3-carboxylic acid (124004-31-5,887408-52-8)

Guidance literature:

3-nitro-1H-pyrazole-5-carboxylic acid; With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 20h; Inert atmosphere;

With sodium hydroxide; In methanol; ethyl acetate; at 20 ℃; for 0.5h;

Reference yield: 80.0%

5-nitropyrazole-3-carboxylic acid (198348-89-9) → 5-amino-1H-pyrazole-3-carboxylic acid (124004-31-5,887408-52-8)

Guidance literature:

With iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate; In water; for 30h; Reflux;

DOI:10.1007/s10593-020-02643-2

Reference yield: 75.0%

3-nitro-1H-pyrazole-5-carboxylic acid → 3-amino-1H-pyrazole-5-carboxylic acid (124004-31-5,887408-52-8)

Guidance literature:

With hydrazine hydrate; In water; at 60 ℃;

DOI:10.1007/s11172-010-0287-9

upstream raw materials:

5-nitropyrazole-3-carboxylic acid

3-amino-5-methylpyrazole

Downstream raw materials:

5-pyridin-2-yl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

5-(3,4-dichloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

7-amino-5-(3,4-dichloro-phenyl)-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid