(5S)-5-tert-butyldiphenylsilyloxymethyl-5,6-dihydroimidazo[1,5-a]pyridine

Base Information

Chemical Name:(5S)-5-tert-butyldiphenylsilyloxymethyl-5,6-dihydroimidazo[1,5-a]pyridine
CAS No.:935553-99-4
Molecular Formula:C₂₄H₂₈N₂OSi
Molecular Weight:388.585
Hs Code.:

Synonyms:(5S)-5-tert-butyldiphenylsilyloxymethyl-5,6-dihydroimidazo[1,5-a]pyridine

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Chemical Property of (5S)-5-tert-butyldiphenylsilyloxymethyl-5,6-dihydroimidazo[1,5-a]pyridine

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Technology Process of (5S)-5-tert-butyldiphenylsilyloxymethyl-5,6-dihydroimidazo[1,5-a]pyridine

There total 3 articles about (5S)-5-tert-butyldiphenylsilyloxymethyl-5,6-dihydroimidazo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: toluene-4-sulfonic acid 2-hydroxy-5-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-pent-4-enyl ester

: 58479-61-1
tert-butylchlorodiphenylsilane

: 935553-98-3
(6R)-6,7-dihydro-5H-imidazo[1,5-a]azepine-6-ol

: 935553-99-4
(5S)-5-tert-butyldiphenylsilyloxymethyl-5,6-dihydroimidazo[1,5-a]pyridine

Guidance literature:: toluene-4-sulfonic acid 2-hydroxy-5-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-pent-4-enyl ester; With sodium hydroxide; In acetone; at 20 ℃; for 12h;

tert-butylchlorodiphenylsilane; With dmap; In pyridine; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2007.01.016

Reference yield:

: 935553-95-0
(R)-(Z)-1-(imidazol-4-yl)pent-1-en-4,5-diol

: 935553-99-4
(5S)-5-tert-butyldiphenylsilyloxymethyl-5,6-dihydroimidazo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 12 h / -10 °C

2.1: aq. NaOH / acetone / 12 h / 20 °C

2.2: 4-dimethylaminopyridine / pyridine / 12 h / 20 °C

With sodium hydroxide; In pyridine; acetone;
DOI:10.1016/j.tet.2007.01.016

Reference yield:

: 935553-93-8
(R)-(Z)-1-[1'-(triphenylmethyl)-1'H-imidazol-4'-yl]-4,5-O-isopropylidene-pent-1-en-4,5-diol

: 935553-99-4
(5S)-5-tert-butyldiphenylsilyloxymethyl-5,6-dihydroimidazo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. HCl / tetrahydrofuran / 6 h / 40 °C

2.1: pyridine / 12 h / -10 °C

3.1: aq. NaOH / acetone / 12 h / 20 °C

3.2: 4-dimethylaminopyridine / pyridine / 12 h / 20 °C

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran; pyridine; acetone;
DOI:10.1016/j.tet.2007.01.016