benzyl 3,5-dimethyl-4-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: benzyl 3,5-dimethyl-4-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylate
• CAS No.: 852160-81-7
• Molecular Formula: C₂₅H₂₈N₂O₃
• Molecular Weight: 404.509
• Mol file: 852160-81-7.mol

Synonyms:benzyl 3,5-dimethyl-4-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylate

Chemical Property of benzyl 3,5-dimethyl-4-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of benzyl 3,5-dimethyl-4-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylate

There total 1 articles about benzyl 3,5-dimethyl-4-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid benzyl ester (852160-79-3) + (R)-1-phenyl-ethyl-amine (3886-69-9) → benzyl 3,5-dimethyl-4-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylate (852160-81-7)

Guidance literature:

With dmap; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/ja0500613

Reference yield:

benzyl 3,5-dimethyl-4-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylate (852160-81-7) → 3,5-dimethyl-4-[2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylic acid

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 16h; under 760 Torr;

DOI:10.1021/ja0500613

Reference yield:

benzyl 3,5-dimethyl-4-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-1H-pyrrole-2-carboxylate (852160-81-7) → Bis{3-[(R)-2-(1-phenyl-ethylcarbamoyl)-ethyl]-2,2',4,4'-tetramethyldipyrromethene} dihydrobromide

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / tetrahydrofuran / 16 h / 760 Torr

2: 0.40 g / aq. HBr / methanol / 0.33 h

With hydrogen bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/ja0500613

upstream raw materials:

4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid benzyl ester

(R)-1-phenyl-ethyl-amine