7-Allyl-4-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol

Base Information

• Chemical Name: 7-Allyl-4-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol
• CAS No.: 107804-87-5
• Molecular Formula: C₁₆H₁₁ClFNO₂
• Molecular Weight: 303.72
• Mol file: 107804-87-5.mol

Synonyms:7-Allyl-4-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol

Chemical Property of 7-Allyl-4-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Allyl-4-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol

There total 3 articles about 7-Allyl-4-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-allyloxy-4-chloro-3-(2-fluorophenyl)-1,2-benzisoxazole (107804-86-4) → 7-Allyl-4-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol (107804-87-5)

Guidance literature:

With N,N-dimethyl-aniline; for 1h; Heating;

DOI:10.1248/cpb.39.1760

Reference yield:

4-chloro-3-(2-fluorophenyl)-6-hydroxy-1,2-benzisoxazole (107804-85-3) → 7-Allyl-4-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol (107804-87-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / K₂CO₃ / dimethylformamide / 2.5 h / 50 - 60 °C

2: 72 percent / N,N-dimethylaniline / 1 h / Heating

With potassium carbonate; N,N-dimethyl-aniline; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.1760

Reference yield:

4-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole (72482-28-1) → 7-Allyl-4-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol (107804-87-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / pyridine hydrochloride / 7 h / 180 - 190 °C

2: 100 percent / K₂CO₃ / dimethylformamide / 2.5 h / 50 - 60 °C

3: 72 percent / N,N-dimethylaniline / 1 h / Heating

With pyridine hydrochloride; potassium carbonate; N,N-dimethyl-aniline; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.1760

upstream raw materials:

6-allyloxy-4-chloro-3-(2-fluorophenyl)-1,2-benzisoxazole

4-chloro-3-(2-fluorophenyl)-6-hydroxy-1,2-benzisoxazole

4-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole

Downstream raw materials:

4-chloro-7,8-dihydro-3-(2-fluorophenyl)furo[2,3-g]-1,2-benzisoxazole-7-methanol

4-chloro-7,8-dihydro-3-(2-fluorophenyl)furo[2,3-g]-1,2-benzisoxazole-7-carboxylic acid