8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamide-2-(hydroxymethyl)quinoline

Base Information

Chemical Name:8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamide-2-(hydroxymethyl)quinoline
CAS No.:607708-59-8
Molecular Formula:C₂₈H₃₁BrN₂O₃SSi
Molecular Weight:583.621
Hs Code.:

Synonyms:8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamide-2-(hydroxymethyl)quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamide-2-(hydroxymethyl)quinoline

Chemical Property:

Purity/Quality:

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Technology Process of 8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamide-2-(hydroxymethyl)quinoline

There total 6 articles about 8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamide-2-(hydroxymethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamido-2-(hydroxymethyl)quinoline

: 607708-59-8
8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamide-2-(hydroxymethyl)quinoline

Guidance literature:: With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/ja0355980

Reference yield:

: 349543-92-6
5-(N,N-dimethyl)sulfonamido-8-hydroxy-2-methylquinoline

: 607708-59-8
8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamide-2-(hydroxymethyl)quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / imidazole / dimethylformamide / 2 h

2: 4A moleculer sieves; selenium dioxide / dioxane / 17 h / 95 °C

3: sodium borohydride / ethanol; CH₂Cl₂ / 0.25 h

4: 538 mg / N-bromosuccinimide; triphenylphosphine / CH₂Cl₂ / 4 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; selenium(IV) oxide; 4 A molecular sieve; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0355980

Reference yield:

: 903877-94-1
8-hydroxy-2-methyl-quinoline-5-sulfonyl chloride

: 607708-59-8
8-tert-butyldiphenylsilyloxy-5-(N,N-dimethyl)sulfonamide-2-(hydroxymethyl)quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / tetrahydrofuran / 3.17 h

2: 57 percent / imidazole / dimethylformamide / 2 h

3: 4A moleculer sieves; selenium dioxide / dioxane / 17 h / 95 °C

4: sodium borohydride / ethanol; CH₂Cl₂ / 0.25 h

5: 538 mg / N-bromosuccinimide; triphenylphosphine / CH₂Cl₂ / 4 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; selenium(IV) oxide; 4 A molecular sieve; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0355980