N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide

Base Information

Chemical Name:N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide
CAS No.:1079393-38-6
Molecular Formula:C₂₅H₂₇FN₆OS
Molecular Weight:478.593
Hs Code.:

Synonyms:N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide

Suppliers and Price of N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide

There total 4 articles about N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 606092-88-0
N-(4-mercaptophenyl)propionamide

: 1079393-42-2
6-chloro-4-(3-cyclopropyl-3-fluoroazetidin-1-yl)-N-(3-methyl-1H-pyrazol-5-yl)pyridin-2-amine

: 1079393-38-6
N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; at 170 - 190 ℃; for 2h; Microwave irradiation;

Reference yield:

: 16063-69-7
2,4,6-trichloropyridine

: 1079393-38-6
N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 1 h / Heating / reflux

2: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 140 - 170 °C / Microwave irradiation

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 2 h / 170 - 190 °C / Microwave irradiation

With sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol;

Reference yield:

: 936548-77-5
3-cyclopropyl-3-fluoroazetidine hydrochloride

: 1079393-38-6
N-(4-[4-{3-cyclopropyl-3-fluoroazetidin-1-yl}-6-{3-methyl-1H-pyrazol-5-ylamino}pyridin-2-ylthio]phenyl)cyclopropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / ethanol / 1 h / Heating / reflux

2: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 140 - 170 °C / Microwave irradiation

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 2 h / 170 - 190 °C / Microwave irradiation

With sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol;