LY-2922470

Base Information

Chemical Name:LY-2922470
CAS No.:1423018-12-5
Molecular Formula:C₂₈H₂₉NO₄S
Molecular Weight:475.609
Hs Code.:

Synonyms:(S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2H)-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid

Suppliers and Price of LY-2922470

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LY2922470
25mg
$ 1260.00

TRC
LY2922470
10mg
$ 605.00

ChemScene
LY2922470 99.87%
10mg
$ 450.00

ChemScene
LY2922470 99.87%
5mg
$ 300.00

ChemScene
LY2922470 99.87%
50mg
$ 1200.00

ChemScene
LY2922470 99.87%
100mg
$ 1900.00

Alichem
(S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2h)-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoicacid
1g
$ 1377.60

Alichem
(S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2h)-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoicacid
250mg
$ 514.50

Total 4 raw suppliers

Chemical Property of LY-2922470

Chemical Property:

Boiling Point:689.1±55.0 °C(Predicted)
PKA:4.19±0.10(Predicted)
Density:1.247±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

LY2922470 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses LY 2922470, has demonstrated potent, efficacious and durable dose dependent reduction in glucose levels along with significant increases in insulin and GLP-1 secretion during preclinical testing. It’s a novel, potent and Selective GPR40 Agonists for the treatment of type 2 Diabetes Mellitus.

Technology Process of LY-2922470

There total 11 articles about LY-2922470 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1423018-16-9
ethyl (S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2H)-yl)-methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoate

: 1423018-12-5
(S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2H)-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid

Guidance literature:: ethyl (S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2H)-yl)-methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoate; With potassium hydroxide; In ethanol; water; at 20 ℃;

With hydrogenchloride; In ethanol; water; pH=6;

Reference yield:

: 108499-32-7
5-bromomethyl-2-carbomethoxythiophene

: 1423018-12-5
(S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2H)-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / ethanol / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -70 °C

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; ethyl acetate / 0 - 20 °C

4.1: potassium hydroxide / ethanol; water / 20 °C

4.2: pH 6

With tributylphosphine; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; ethyl acetate; toluene;

Reference yield:

: 1423018-14-7
methyl 5-[(8-methoxy-3,4-dihydro-2H-quinolin-1-yl)methyl]thiophene-2-carboxylate

: 1423018-12-5
(S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2H)-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -70 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; ethyl acetate / 0 - 20 °C

3.1: potassium hydroxide / ethanol; water / 20 °C

3.2: pH 6

With tributylphosphine; diisobutylaluminium hydride; potassium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; ethyl acetate; toluene;