<<1-<(tert-butyloxycarbonyl)methyl>-1H-indol-3-yl>carbonyl>-(2S,4R)Hyp-Phe-NMeBzl

Base Information

Chemical Name:<<1-<(tert-butyloxycarbonyl)methyl>-1H-indol-3-yl>carbonyl>-(2S,4R)Hyp-Phe-NMeBzl
CAS No.:131948-49-7
Molecular Formula:C₃₇H₄₂N₄O₆
Molecular Weight:638.764
Hs Code.:

Synonyms:<<1-<(tert-butyloxycarbonyl)methyl>-1H-indol-3-yl>carbonyl>-(2S,4R)Hyp-Phe-NMeBzl

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Chemical Property of <<1-<(tert-butyloxycarbonyl)methyl>-1H-indol-3-yl>carbonyl>-(2S,4R)Hyp-Phe-NMeBzl

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Technology Process of <<1-<(tert-butyloxycarbonyl)methyl>-1H-indol-3-yl>carbonyl>-(2S,4R)Hyp-Phe-NMeBzl

There total 5 articles about <<1-<(tert-butyloxycarbonyl)methyl>-1H-indol-3-yl>carbonyl>-(2S,4R)Hyp-Phe-NMeBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.8%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 131948-20-4
(1H-indol-3-ylcarbonyl)-(2S,2R)Hyp-Phe-NMeBzl

: 131948-49-7
<<1-<(tert-butyloxycarbonyl)methyl>-1H-indol-3-yl>carbonyl>-(2S,4R)Hyp-Phe-NMeBzl

Guidance literature:: With sodium hydroxide; cetyltrimethylammonium chloride; In dichloromethane; for 1h;
DOI:10.1021/jm00039a022

Reference yield:

: 126090-31-1
N^α-(tert-butoxycarbonyl)-L-phenylalanine-N-benzyl-N-methylamide

: 131948-49-7
<<1-<(tert-butyloxycarbonyl)methyl>-1H-indol-3-yl>carbonyl>-(2S,4R)Hyp-Phe-NMeBzl

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / ethyl acetate / Ambient temperature

2: 100 percent / HOBT, WSCD / CH₂Cl₂ / Ambient temperature

3: HCl / dioxane; CH₂Cl₂ / 1 h / Ambient temperature

4: bis(trimethylsilyl)acetamide / CH₂Cl₂

5: 67.8 percent / cetyltrimethylammonium chloride, NaOH / CH₂Cl₂ / 1 h

With hydrogenchloride; sodium hydroxide; cetyltrimethylammonium chloride; benzotriazol-1-ol; bis-(trimethylsilyl)acetamide; In 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/jm00039a022

Reference yield:

: 126090-32-2,1236259-31-6
N-methyl-N-(phenylmethyl)-L-phenylalaninamide hydrochloride

: 131948-49-7
<<1-<(tert-butyloxycarbonyl)methyl>-1H-indol-3-yl>carbonyl>-(2S,4R)Hyp-Phe-NMeBzl

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / HOBT, WSCD / CH₂Cl₂ / Ambient temperature

2: HCl / dioxane; CH₂Cl₂ / 1 h / Ambient temperature

3: bis(trimethylsilyl)acetamide / CH₂Cl₂

4: 67.8 percent / cetyltrimethylammonium chloride, NaOH / CH₂Cl₂ / 1 h

With hydrogenchloride; sodium hydroxide; cetyltrimethylammonium chloride; benzotriazol-1-ol; bis-(trimethylsilyl)acetamide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00039a022