5-tert-butyloxycarbonyl-6-methyl-4-(2-chloro-phenyl)-3,4-dihydropyrimidin-2-(1H)-thione

Base Information

• Chemical Name: 5-tert-butyloxycarbonyl-6-methyl-4-(2-chloro-phenyl)-3,4-dihydropyrimidin-2-(1H)-thione
• CAS No.: 488826-55-7
• Molecular Formula: C₁₆H₁₉ClN₂O₂S
• Molecular Weight: 338.858
• Mol file: 488826-55-7.mol

Synonyms:5-tert-butyloxycarbonyl-6-methyl-4-(2-chloro-phenyl)-3,4-dihydropyrimidin-2-(1H)-thione

Chemical Property of 5-tert-butyloxycarbonyl-6-methyl-4-(2-chloro-phenyl)-3,4-dihydropyrimidin-2-(1H)-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-tert-butyloxycarbonyl-6-methyl-4-(2-chloro-phenyl)-3,4-dihydropyrimidin-2-(1H)-thione

There total 2 articles about 5-tert-butyloxycarbonyl-6-methyl-4-(2-chloro-phenyl)-3,4-dihydropyrimidin-2-(1H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl acetoacetate (1694-31-1) + 2-chloro-benzaldehyde (89-98-5) + thiourea (17356-08-0) → 5-tert-butyloxycarbonyl-6-methyl-4-(2-chloro-phenyl)-3,4-dihydropyrimidin-2-(1H)-thione (488826-55-7)

Guidance literature:

With L-proline N-sulfonic acid functionalized magnetic nanoparticle; In neat (no solvent); at 100 ℃; for 3h; Green chemistry;

DOI:10.1039/c6ra10558k

Reference yield: 46.0%

tert-butyl acetoacetate (1694-31-1) + 2-chloro-benzaldehyde (89-98-5) + thiourea (17356-08-0) → 6-tert-butyloxycarbonyl-5-methyl-4-(2-chloro-phenyl)-3,4-dihydropyrimidin-2-(1H)-thione (1131184-77-4) + 5-tert-butyloxycarbonyl-6-methyl-4-(2-chloro-phenyl)-3,4-dihydropyrimidin-2-(1H)-thione (488826-55-7)

Guidance literature:

With ytterbium picrate; C₄₆H₃₆N₂O₅; In tetrahydrofuran; at 20 ℃; for 60h;

DOI:10.1246/cl.2009.56

upstream raw materials:

tert-butyl acetoacetate

2-chloro-benzaldehyde

thiourea