((1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropoxy)diphenylphosphine

Base Information

Chemical Name:((1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropoxy)diphenylphosphine
CAS No.:1312540-22-9
Molecular Formula:C₃₀H₃₁O₂PS
Molecular Weight:486.615
Hs Code.:

Synonyms:((1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropoxy)diphenylphosphine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropoxy)diphenylphosphine

Chemical Property:

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Technology Process of ((1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropoxy)diphenylphosphine

There total 3 articles about ((1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropoxy)diphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1312540-21-8
(1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropan-1-ol

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 1312540-22-9
((1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropoxy)diphenylphosphine

Guidance literature:: With dmap; triethylamine; In toluene; at 20 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.050

Reference yield:

: 1221576-20-0
(1R,2S)-1-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropan-2-ol

: 1312540-22-9
((1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropoxy)diphenylphosphine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid / tetrahydrofuran; toluene / 17 h / -20 - 20 °C / Inert atmosphere

1.2: 19 h / -20 °C / Inert atmosphere

1.3: Inert atmosphere; aq. buffer

2.1: dmap; triethylamine / toluene / 0.33 h / 20 °C / Inert atmosphere

With dmap; triethylamine; triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; toluene;
DOI:10.1016/j.tet.2011.04.050

Reference yield:

: 38360-81-5
3,5-Dimethylthiophenol

: 1312540-22-9
((1S,2R)-2-(3,5-dimethylphenylthio)-3-methoxy-1-phenylpropoxy)diphenylphosphine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / 1,4-dioxane; water / Heating

2.1: triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid / tetrahydrofuran; toluene / 17 h / -20 - 20 °C / Inert atmosphere

2.2: 19 h / -20 °C / Inert atmosphere

2.3: Inert atmosphere; aq. buffer

3.1: dmap; triethylamine / toluene / 0.33 h / 20 °C / Inert atmosphere

With dmap; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; 1,4-dioxane; water; toluene;
DOI:10.1016/j.tet.2011.04.050