(E)-3-bromo-2-(hydroxymethyl)-4-(2-nitrophenylsulfonamido)but-2-enyl acetate

Base Information

• Chemical Name: (E)-3-bromo-2-(hydroxymethyl)-4-(2-nitrophenylsulfonamido)but-2-enyl acetate
• CAS No.: 1442642-76-3
• Molecular Formula: C₁₃H₁₅BrN₂O₇S
• Molecular Weight: 423.241
• Mol file: 1442642-76-3.mol

Synonyms:(E)-3-bromo-2-(hydroxymethyl)-4-(2-nitrophenylsulfonamido)but-2-enyl acetate

Chemical Property of (E)-3-bromo-2-(hydroxymethyl)-4-(2-nitrophenylsulfonamido)but-2-enyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-3-bromo-2-(hydroxymethyl)-4-(2-nitrophenylsulfonamido)but-2-enyl acetate

There total 1 articles about (E)-3-bromo-2-(hydroxymethyl)-4-(2-nitrophenylsulfonamido)but-2-enyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-(2-bromo-4-hydroxy-3-(hydroxymethyl)but-2-enyl)-2-nitrobenzenesulfonamide (1442642-86-5) + acetic anhydride (108-24-7) → (E)-3-bromo-2-(hydroxymethyl)-4-(2-nitrophenylsulfonamido)but-2-enyl acetate (1442642-76-3) + 2-(1-bromo-2-(2-nitrophenylsulfonamido)ethylidene)propane-1,3-diyl diacetate (1442642-77-4)

Guidance literature:

With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(2-naphthylmethyl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine; In tetrahydrofuran; chloroform; at -60 ℃; for 24h; diastereoselective reaction;

DOI:10.1002/adsc.201200242

upstream raw materials:

N-(2-bromo-4-hydroxy-3-(hydroxymethyl)but-2-enyl)-2-nitrobenzenesulfonamide

acetic anhydride