3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-tert-butyldimethylsilyloxypentyl)-1-β-D-arabinofuranosyluracil

Base Information

• Chemical Name: 3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-tert-butyldimethylsilyloxypentyl)-1-β-D-arabinofuranosyluracil
• CAS No.: 1058146-45-4
• Molecular Formula: C₄₁H₄₇FN₂O₉Si
• Molecular Weight: 758.916
• Mol file: 1058146-45-4.mol

Synonyms:3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-tert-butyldimethylsilyloxypentyl)-1-β-D-arabinofuranosyluracil

Chemical Property of 3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-tert-butyldimethylsilyloxypentyl)-1-β-D-arabinofuranosyluracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-tert-butyldimethylsilyloxypentyl)-1-β-D-arabinofuranosyluracil

There total 1 articles about 3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-tert-butyldimethylsilyloxypentyl)-1-β-D-arabinofuranosyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

1-bromo-5-(tert-butyldimethylsilyloxy)pentane (85514-43-8) + 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N3-benzoyl-5-iodouracil (157428-24-5) → 3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-tert-butyldimethylsilyloxypentyl)-1-β-D-arabinofuranosyluracil (1058146-45-4)

Guidance literature:

1-bromo-5-(tert-butyldimethylsilyloxy)pentane; With iodine; zinc; In N,N-dimethyl acetamide; at 80 ℃; Inert atmosphere;

1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N³-benzoyl-5-iodouracil; With bis(tri-t-butylphosphine)palladium⁽⁰⁾; In N,N-dimethyl acetamide; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jm800501d

Reference yield: 99.0%

3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-tert-butyldimethylsilyloxypentyl)-1-β-D-arabinofuranosyluracil (1058146-45-4) → 3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-hydroxypentyl)-1-β-D-arabinofuranosyluracil (1058146-50-1)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/jm800501d

upstream raw materials:

1-bromo-5-(tert-butyldimethylsilyloxy)pentane

1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N³-benzoyl-5-iodouracil

Downstream raw materials:

3-N-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-deoxy-5-(5-hydroxypentyl)-1-β-D-arabinofuranosyluracil