1-(4'-fluorobiphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

Base Information

Chemical Name:1-(4'-fluorobiphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one
CAS No.:1527518-40-6
Molecular Formula:C₂₀H₂₀FN₃O₂
Molecular Weight:353.396
Hs Code.:

Synonyms:1-(4'-fluorobiphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

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Chemical Property of 1-(4'-fluorobiphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

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Technology Process of 1-(4'-fluorobiphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

There total 3 articles about 1-(4'-fluorobiphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1765-93-1
4-fluoroboronic acid

: 43121-43-3
1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

: 1527518-40-6
1-(4'-fluorobiphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

Guidance literature:: With palladium on activated charcoal; potassium carbonate; CyJohnPhos; In N,N-dimethyl acetamide; water; at 80 ℃; for 48h; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.tet.2013.11.067

Reference yield: 84.0%

: 352-34-1
4-fluoro-1-iodobenzene

: 1527518-38-2
3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-1-(4-(trimethylstannyl)phenoxy)butan-2-one

: 1527518-40-6
1-(4'-fluorobiphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; cesium fluoride; In toluene; at 100 ℃; for 48h; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.tet.2013.11.067

Reference yield:

: 43121-43-3
1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

: 1527518-40-6
1-(4'-fluorobiphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium; ammonia

1.2: 1.5 h / UV-irradiation

2.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; cesium fluoride; copper(l) iodide / toluene / 48 h / 100 °C / Schlenk technique; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ammonia; sodium; triphenylphosphine; cesium fluoride; In toluene; 2.1: |Stille Cross Coupling;
DOI:10.1016/j.tet.2013.11.067