N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)-2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetamide

Base Information

Chemical Name:N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)-2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetamide
CAS No.:1602747-13-6
Molecular Formula:C₃₅H₂₈FN₃O₄
Molecular Weight:573.623
Hs Code.:

Synonyms:N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)-2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetamide

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Chemical Property of N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)-2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetamide

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Technology Process of N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)-2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetamide

There total 4 articles about N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)-2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1602748-22-0
2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetatic acid

: 5-(biphenyl-4-yloxy)-2-fluoroaniline

: 1602747-13-6
N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)-2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetamide

Guidance literature:: With triethylamine; HATU; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2016.11.017

Reference yield:

: 1602748-19-5
methyl 2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetate

: 1602747-13-6
N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)-2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 20 °C / Inert atmosphere

2: HATU; triethylamine / acetonitrile / 20 °C / Inert atmosphere

With triethylamine; HATU; sodium hydroxide; In methanol; acetonitrile;
DOI:10.1016/j.ejmech.2016.11.017

Reference yield:

: 926583-68-8
N-(2-iodophenyl)-2,5-dimethoxybenzamide

: 1602747-13-6
N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)-2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; L-proline; sodium hydroxide; ammonium hydroxide / dimethyl sulfoxide; water / 3 h / 20 °C / Inert atmosphere

1.2: 7 h / 80 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / methanol / 20 °C / Inert atmosphere

4.1: HATU; triethylamine / acetonitrile / 20 °C / Inert atmosphere

With ammonium hydroxide; copper(l) iodide; sodium hydride; triethylamine; HATU; L-proline; sodium hydroxide; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1.1: |Ullmann Condensation;
DOI:10.1016/j.ejmech.2016.11.017