methyl 7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

Base Information

• Chemical Name: methyl 7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate
• CAS No.: 121127-01-3
• Molecular Formula: C₂₆H₃₃FO₄
• Molecular Weight: 428.544
• Mol file: 121127-01-3.mol

Synonyms:methyl 7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

Chemical Property of methyl 7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate

There total 2 articles about methyl 7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 7-(4-fluorophenyl)-7-<3-(1-hydroxyethyl)-60methoxy-2,4,5-trimethylphenyl>heptanoate (121099-68-1) → methyl 7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate (121127-01-3)

Guidance literature:

With manganese(IV) oxide; In benzene; for 1.5h;

DOI:10.1021/jm00090a009

Reference yield:

methyl (R)-7-(4-flurophenyl)-7-(3-formyl-6-methoxy-2,4,5-trimethylphenyl)heptanoate (121099-67-0) → methyl 7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate (121127-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / tetrahydrofuran / -78 °C

2: 93 percent / MnO₂ / benzene / 1.5 h

With manganese(IV) oxide; In tetrahydrofuran; benzene;

DOI:10.1021/jm00090a009

Reference yield: 58.0%

methyl 7-(3-acetyl-6-methoxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoate (121127-01-3) → 7-(3-acetyl-6-hydroxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid (121099-98-7)

Guidance literature:

With boron tribromide; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1021/jm00090a009

upstream raw materials:

methyl 7-(4-fluorophenyl)-7-<3-(1-hydroxyethyl)-60methoxy-2,4,5-trimethylphenyl>heptanoate

methyl (R)-7-(4-flurophenyl)-7-(3-formyl-6-methoxy-2,4,5-trimethylphenyl)heptanoate

Downstream raw materials:

7-(3-acetyl-6-hydroxy-2,4,5-trimethylphenyl)-7-(4-fluorophenyl)heptanoic acid