2-[4-(2-Cyclohexyl-ethyl)-phenyl]-ethylamine

Base Information

• Chemical Name: 2-[4-(2-Cyclohexyl-ethyl)-phenyl]-ethylamine
• CAS No.: 124499-31-6
• Molecular Formula: C16H25 N
• Molecular Weight: 231.38
• DSSTox Substance ID: DTXSID30567318
• Wikidata: Q82453167
• Mol file: 124499-31-6.mol

Synonyms:124499-31-6;2-[4-(2-CYCLOHEXYL-ETHYL)-PHENYL]-ETHYLAMINE;2-[4-(2-cyclohexylethyl)phenyl]ethanamine;2-(4-(2-Cyclohexylethyl)phenyl)ethanamine;SCHEMBL9763012;DTXSID30567318;IFWGVWBAKRWCQH-UHFFFAOYSA-N;p-(2-cyclohexylethyl)-phenethylamine;SB32148;2-[4-(2-Cyclohexyl-ethyl)phenyl]-ethylamine;2-[4-(2-cyclohexylethyl)phenyl]ethan-1-amine;A805248

Chemical Property of 2-[4-(2-Cyclohexyl-ethyl)-phenyl]-ethylamine

Chemical Property:

• PSA: 26.02000
• LogP: 4.40100
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 231.198699802
• Heavy Atom Count: 17
• Complexity: 188

Purity/Quality:

97% ^*data from raw suppliers

2-[4-(2-CYCLOHEXYL-ETHYL)PHENYL]-ETHYLAMINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)CCC2=CC=C(C=C2)CCN

Technology Process of 2-[4-(2-Cyclohexyl-ethyl)-phenyl]-ethylamine

There total 4 articles about 2-[4-(2-Cyclohexyl-ethyl)-phenyl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-<2-<4-(2-cyclohexylethyl)phenyl>ethyl>phthalimide (124499-32-7) → 2-<4-(2-cyclohexylethyl)phenyl>ethylamine (124499-31-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 18h; Heating;

DOI:10.1021/jm00112a035

Reference yield:

4-Bromophenethylamine (73918-56-6) → 2-<4-(2-cyclohexylethyl)phenyl>ethylamine (124499-31-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / acetic acid / 18 h / Heating

2: 46 percent / palladium acetate, tri-o-tolylphosphine, triethylamine / 18 h / Heating

3: 80 percent / H₂ / 10percent Pd/C / ethyl acetate / 6 h / 2585.7 Torr

4: 81 percent / hydrazine hydrate / ethanol / 18 h / Heating

With hydrogen; palladium diacetate; hydrazine hydrate; acetic acid; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jm00112a035

Reference yield:

2-(2-(4-bromophenyl)ethyl)isoindolin-1,3-dione (124499-18-9) → 2-<4-(2-cyclohexylethyl)phenyl>ethylamine (124499-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / palladium acetate, tri-o-tolylphosphine, triethylamine / 18 h / Heating

2: 80 percent / H₂ / 10percent Pd/C / ethyl acetate / 6 h / 2585.7 Torr

3: 81 percent / hydrazine hydrate / ethanol / 18 h / Heating

With hydrogen; palladium diacetate; hydrazine hydrate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jm00112a035

upstream raw materials:

N-<2-<4-(2-cyclohexylethyl)phenyl>ethyl>phthalimide

4-Bromophenethylamine

2-(2-(4-bromophenyl)ethyl)isoindolin-1,3-dione

Downstream raw materials:

2-[2-(p-2-cyclohexylethyl-phenyl)-ethylamino]-adenosine

Refernces