1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid

Base Information

Chemical Name:1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS No.:124492-04-2
Molecular Formula:C₇H₁₁NO₂S₂
Molecular Weight:205.302
Hs Code.:
DSSTox Substance ID:DTXSID40510476
Mol file:124492-04-2.mol

Synonyms:1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid;124492-04-2;(S)-1,4-DITHIA-7-AZASPIRO[4.4]NONANE-8-CARBOXYLIC ACID;SCHEMBL1133786;DTXSID40510476;A846928

Suppliers and Price of 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid

Chemical Property:

Boiling Point:427.372 °C at 760 mmHg
Flash Point:212.267 °C
PSA：99.93000
Density:1.479 g/cm³
LogP:0.93800
XLogP3:-1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:205.02312094
Heavy Atom Count:12
Complexity:204

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CSC2(S1)CC(NC2)C(=O)O

Technology Process of 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid

There total 4 articles about 1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64187-47-9
1-benzyloxycarbonyl-4-keto-L-proline

: 83552-44-7,124492-04-2
1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 6.8 g / SOCl₂ / 20 h / Heating

2: 3.86 g / p-toluenesulfonic acid / acetic acid / 44 h / Heating

3: 6.3 g / 20percent HBr/glacial acetic acid / 2 h / Ambient temperature

4: 3.64 g / 2.5 N aq. NaOH / methanol / 18 h / Ambient temperature

With sodium hydroxide; thionyl chloride; hydrogen bromide; toluene-4-sulfonic acid; acetic acid; In methanol; acetic acid;
DOI:10.1021/jm00127a033

Reference yield:

: 1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid ethyl ester hydrobromide

: 83552-44-7,124492-04-2
1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; for 18h; Ambient temperature;
DOI:10.1021/jm00127a033

Reference yield:

: 83507-89-5
N-<(phenylmethoxy)carbonyl>-4-oxo-(S)-proline ethyl ester

: 83552-44-7,124492-04-2
1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 3.86 g / p-toluenesulfonic acid / acetic acid / 44 h / Heating

2: 6.3 g / 20percent HBr/glacial acetic acid / 2 h / Ambient temperature

3: 3.64 g / 2.5 N aq. NaOH / methanol / 18 h / Ambient temperature

With sodium hydroxide; hydrogen bromide; toluene-4-sulfonic acid; acetic acid; In methanol; acetic acid;
DOI:10.1021/jm00127a033