2-Oxazolidinone,4-(hydroxymethyl)-5-(1-methylethyl)-,(4R,5S)-(9CI)

Base Information

• Chemical Name: 2-Oxazolidinone,4-(hydroxymethyl)-5-(1-methylethyl)-,(4R,5S)-(9CI)
• CAS No.: 125414-63-3
• Molecular Formula: C7H13 N O3
• Molecular Weight: 159.185
• Mol file: 125414-63-3.mol

Synonyms:2-Oxazolidinone,4-(hydroxymethyl)-5-(1-methylethyl)-, (4R-cis)-

Chemical Property of 2-Oxazolidinone,4-(hydroxymethyl)-5-(1-methylethyl)-,(4R,5S)-(9CI)

Chemical Property:

• PSA: 58.56000
• LogP: 0.44050

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Oxazolidinone,4-(hydroxymethyl)-5-(1-methylethyl)-,(4R,5S)-(9CI)

There total 9 articles about 2-Oxazolidinone,4-(hydroxymethyl)-5-(1-methylethyl)-,(4R,5S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1S,7aR)-1-Isopropyl-5,5-dimethyl-dihydro-oxazolo[3,4-c]oxazol-3-one (182958-39-0) → 4-(4S)-hydroxymethyl-5-(5R)-isopropyloxazolidin-2-one (125414-63-3,127870-57-9)

Guidance literature:

With boron trifluoride; acetic acid; In methanol; for 3h; Ambient temperature;

DOI:10.1016/0040-4020(96)00672-2

Reference yield: 97.0%

Trichloro-acetic acid (4R,5S)-5-isopropyl-2-oxo-oxazolidin-4-ylmethyl ester (125414-60-0) → 4-(4S)-hydroxymethyl-5-(5R)-isopropyloxazolidin-2-one (125414-63-3,127870-57-9)

Guidance literature:

With sodium hydroxide; In methanol; for 5h; Ambient temperature;

DOI:10.1055/s-1989-27216

Reference yield: 80.0%

(7'S,7'aR)-dihydroxy-7'-isopropylspirooxazolo<3,4-c>oxazol>-5'-one (171623-09-9) → 4-(4S)-hydroxymethyl-5-(5R)-isopropyloxazolidin-2-one (125414-63-3,127870-57-9)

Guidance literature:

With boron trifluoride diacetate; In methanol;

DOI:10.1016/0040-4039(95)01456-R

upstream raw materials:

Trichloro-acetic acid (4R,5S)-5-isopropyl-2-oxo-oxazolidin-4-ylmethyl ester

(7'S,7'aR)-dihydroxy-7'-isopropylspirooxazolo<3,4-c>oxazol>-5'-one

(1S,7aR)-1-Isopropyl-5,5-dimethyl-dihydro-oxazolo[3,4-c]oxazol-3-one

(4R)-4-((1R)-1-hydroxy-2-methyl-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Downstream raw materials:

(4S,5S)-5-Isopropyl-2-oxazolidinone-4-carboxylic acid

(2S,3S)-3-{4-[2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-ethyl]-phenoxy}-2-tert-butoxycarbonylamino-4-methyl-pentanoic acid

(2S,3S)-3-{4-[2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-1-hydroxy-ethyl]-phenoxy}-2-tert-butoxycarbonylamino-4-methyl-pentanoic acid pentafluorophenyl ester

(2S,3S)-3-{4-[2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-acetyl]-phenoxy}-2-tert-butoxycarbonylamino-4-methyl-pentanoic acid

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