N-(1-PYRIDIN-2-YL-ETHYL)-HYDROXYLAMINE

Base Information

• Chemical Name: N-(1-PYRIDIN-2-YL-ETHYL)-HYDROXYLAMINE
• CAS No.: 127104-26-1
• Molecular Formula: C7H10 N2 O
• Molecular Weight: 138.17
• Hs Code.: 2933399090
• Mol file: 127104-26-1.mol

Synonyms:2-Pyridinemethanamine,N-hydroxy-a-methyl-, (?à)-

Chemical Property of N-(1-PYRIDIN-2-YL-ETHYL)-HYDROXYLAMINE

Chemical Property:

• Vapor Pressure: 0.00435mmHg at 25°C
• Refractive Index: 1.549
• Boiling Point: 266.3°Cat760mmHg
• Flash Point: 114.8°C
• PSA: 45.15000
• Density: 1.127g/cm³
• LogP: 1.51230

Purity/Quality:

98% ^*data from raw suppliers

N-(1-PYRIDIN-2-YL-ETHYL)-HYDROXYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(1-PYRIDIN-2-YL-ETHYL)-HYDROXYLAMINE

There total 2 articles about N-(1-PYRIDIN-2-YL-ETHYL)-HYDROXYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

1-pyridin-2-yl-ethanone oxime (1758-54-9,79462-42-3,81563-77-1) → N-hydroxy-1-(2-pyridyl)ethanamine (127104-26-1)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In methanol; for 21h; Ambient temperature;

DOI:10.1021/jo00298a018

Reference yield:

2-acetylpyridine (1122-62-9) → N-hydroxy-1-(2-pyridyl)ethanamine (127104-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent

2: 31 percent / 2N HCl, sodium cyanoborohydride / methanol / 21 h / Ambient temperature

With hydrogenchloride; sodium cyanoborohydride; In methanol;

DOI:10.1021/jo00298a018

Reference yield: 74.0%

N-hydroxy-1-(2-pyridyl)ethanamine (127104-26-1) + benzaldehyde (100-52-7) → N-benzylidene-1-(2-pyridyl)ethanamine N-oxide (127104-30-7)

Guidance literature:

With sodium sulfate; In dichloromethane; Ambient temperature;

DOI:10.1021/jo00298a018

upstream raw materials:

1-pyridin-2-yl-ethanone oxime

2-acetylpyridine

Downstream raw materials:

N-benzylidene-1-(2-pyridyl)ethanamine N-oxide

(R*,S*)-N-hydroxy-N-<1-(1-pyridyl)ethyl>-1-phenylethanamine

(R*,R*)-N-hydroxy-N-<1-(1-pyridyl)ethyl>-1-phenylethanamine

Refernces