HEXAHYDRO-CYCLOPENTA[C]PYRROL-4-ONE HYDROCHLORIDE

Base Information

• Chemical Name: HEXAHYDRO-CYCLOPENTA[C]PYRROL-4-ONE HYDROCHLORIDE
• CAS No.: 127430-46-0
• Molecular Formula: C₇H₁₁NO*ClH
• Molecular Weight: 161.631
• Hs Code.: 2933990090
• Mol file: 127430-46-0.mol

Synonyms:Cyclopenta[c]pyrrol-4(1H)-one,hexahydro-, hydrochloride (9CI)

Chemical Property of HEXAHYDRO-CYCLOPENTA[C]PYRROL-4-ONE HYDROCHLORIDE

Chemical Property:

• PSA: 29.10000
• LogP: 1.31570

Purity/Quality:

97% ^*data from raw suppliers

Hexahydro-cyclopenta[c]pyrrol-4-one hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HEXAHYDRO-CYCLOPENTA[C]PYRROL-4-ONE HYDROCHLORIDE

There total 1 articles about HEXAHYDRO-CYCLOPENTA[C]PYRROL-4-ONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

→ hexahydrocyclopenta[c]pyrrol-4(5H)-one hydrochloride (127430-46-0)

Guidance literature:

Reference yield: 54.0%

hexahydrocyclopenta[c]pyrrol-4(5H)-one hydrochloride (127430-46-0) + di-tert-butyl dicarbonate (24424-99-5) → 4-oxohexahydrocyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester (879686-42-7,130658-14-9)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 20 ℃; for 1h;

Reference yield:

(rac)-hexahydrocyclopenta[c]pyrrol-4(2H)-one hydrochloride (127430-46-0) → (rac)-cis-methyl 4-hydroxy-4-(m-tolylethynyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; dmap / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

2.1: ethylmagnesium bromide / tetrahydrofuran / 2 h / 0 - 50 °C

2.2: 1.5 h / 50 °C

With dmap; ethylmagnesium bromide; triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2013.09.059

Downstream raw materials:

4-oxohexahydrocyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester

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