1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine

Base Information

• Chemical Name: 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine
• CAS No.: 127561-18-6
• Molecular Formula: C10H12 F3 N3
• Molecular Weight: 231.221
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50465463
• Wikidata: Q82291423
• Mol file: 127561-18-6.mol

Synonyms:127561-18-6;1-[6-(trifluoromethyl)pyridin-2-yl]piperazine;1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine;2-Piperazino-6-(trifluoromethyl)pyridine;Piperazine, 1-[6-(trifluoromethyl)-2-pyridinyl]-;1-[6-(trifluoromethyl)-2-pyridyl]piperazine;1-(6-Trifluoromethyl)-2-pyridinyl piperazine;SCHEMBL255005;DTXSID50465463;CHEBI:195125;ZAKBQHKAPKXFOJ-UHFFFAOYSA-N;GS0798;MFCD00114706;AKOS011050548;AC-9343;FS-2047;4-(6-trifluoromethyl-2-pyridyl)piperazine;CS-0444140;FT-0710997;1-[6-(triluoromethyl)pyridin-2-yl]piperazine;1-[6-(trifluoromethyl)-2-pyridinyl]piperazine;1-[6-(trifluoromethyl) -2-pyridinyl]piperazine;1-[6-(trifluoromethyl)-2-pyridinyl]-piperazine;A805711;1-[6-(TRIFLUOROMETHYL)PYRIDIN-2-YL] PIPERAZINE;1-[6-(trifluoromethyl)pyridin-2-yl]piperazine, AldrichCPR

Chemical Property of 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine

Chemical Property:

• Vapor Pressure: 0.000378mmHg at 25°C
• Refractive Index: 1.331
• Boiling Point: 58.1°Cat760mmHg
• PKA: 8.45±0.10(Predicted)
• Flash Point: °C
• PSA: 28.16000
• Density: 1.578g/cm³
• LogP: 1.90380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 231.09833188
• Heavy Atom Count: 16
• Complexity: 226

Purity/Quality:

99%, ^*data from raw suppliers

1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C2=CC=CC(=N2)C(F)(F)F

Technology Process of 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine

There total 2 articles about 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

piperazine (110-85-0) + 2-chloro-6-trifluoromethylpyridine (39890-95-4) → 1-[6-(trifluoromethyl)-2-pyridinyl]-piperazine (127561-18-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 200 ℃; for 0.666667h; microwave irradiation;

DOI:10.1021/jm060065y

Reference yield:

→ 1-[6-(trifluoromethyl)-2-pyridinyl]-piperazine (127561-18-6)

Guidance literature:

Reference yield: 100.0%

4-(pyridin-3-yloxy)phenyl sulfurofluoridate + 1-[6-(trifluoromethyl)-2-pyridinyl]-piperazine (127561-18-6) → 4-(pyridin-3-yloxy)phenyl 4-(6-(trifluoromethyl)pyridin-2-yl)piperazine-1-sulfonate

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; calcium(II) bis(trifluoromethanesulfonyl)imide; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1021/acs.orglett.0c01397

upstream raw materials:

piperazine

2-chloro-6-trifluoromethylpyridine

Downstream raw materials:

4-nitro-N-{2-[4-(6-trifluoromethylpyridin-2-yl)piperazin-1-yl]ethyl}benzamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 127561-18-6 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine

Send

Send

Metric Ton KG G Pound L ML

Send

Send