Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 127828-22-2
• Molecular Formula: C9H20 N2 O3
• Molecular Weight: 204.269
• Hs Code.: 2924199090
• Mol file: 127828-22-2.mol

Synonyms:Carbamicacid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.457
• Boiling Point: 321.128°C at 760 mmHg
• PKA: 12.24±0.46(Predicted)
• Flash Point: 148.013°C
• PSA: 77.07000
• Density: 1.024g/cm³
• LogP: 1.39110
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl(2-(2-aminoethoxy)ethyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: t-Boc-N-Amido-PEG1-amine is a small molecule PEG reagent containing an amino group and Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

There total 10 articles about Carbamic acid, [2-(2-aminoethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(2-(tert-Butoxycarbonylamino)ethoxy)-2-azidoethane (176220-30-7) → tert-butyl 2-(2-aminoethoxy)ethylcarbamate (127828-22-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃; for 8h;

DOI:10.1016/j.ejmech.2016.04.001

Reference yield: 97.0%

2,2'-diaminodiethyl ether (2752-17-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 2-(2-aminoethoxy)ethylcarbamate (127828-22-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

DOI:10.1016/j.tetlet.2006.02.119

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-(2-aminoethoxy)ethanamine dihydrochloride (60792-79-2) → tert-butyl 2-(2-aminoethoxy)ethylcarbamate (127828-22-2) + di-tert-butyl 3-oxapentane-1,5-diyldicarbamate

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 24h;

DOI:10.1002/1099-0690(200209)2002:17<3004::AID-EJOC3004>3.0.CO;2-O

upstream raw materials:

di-tert-butyl dicarbonate

2-(2-aminoethoxy)ethanamine dihydrochloride

2,2'-diaminodiethyl ether

1-(2-(tert-Butoxycarbonylamino)ethoxy)-2-azidoethane

Downstream raw materials:

N-(2-(tert-butoxycarbonylamino)ethoxyethyl) N_α-benzyloxycarbonyl-D-arginine amide

C₃₉H₇₂O₁₂N₆

C₃₆H₆₆N₆O₁₂

C₃₆H₆₀N₆O₁₂

Refernces

• 1、 Brindisi, Margherita,Maramai, Samuele,Brogi, Simone,Fanigliulo, Emanuela,Butini, Stefania,Guarino, Egeria,Casagni, Alice,Lamponi, Stefania,Bonechi, Claudia,Nathwani, Seema M.,Finetti, Federica,Ragonese, Francesco,Arcidiacono, Paola,Campiglia, Pietro,Valenti, Salvatore,Novellino, Ettore,Spaccapelo, Roberta,Morbidelli, Lucia,Zisterer, Daniela M.,Williams, Clive D.,Donati, Alessandro,Baldari, Cosima,Campiani, Giuseppe,Ulivieri, Cristina,Gemma, Sandra. "Development of novel cyclic peptides as pro-apoptotic agents". . p. 301 - 320. Retrieved 2016.
• 2、 Suzuki, Hiroyuki,Kanai, Ayaka,Uehara, Tomoya,Guerra Gomez, Francisco L.,Hanaoka, Hirofumi,Arano, Yasushi. "Facile synthesis and evaluation of C-functionalized benzyl-1-oxa-4,7,10- triazacyclododecane-N,N′,N″-triacetic acid as chelating agent for 111In-labeled polypeptides". . p. 978 - 984. Retrieved 2012.
• 3、 Tu, Yalin,Sun, Yameng,Qiao, Shuang,Luo, Yao,Liu, Panpan,Jiang, Zhong-Xing,Hu, Yumin,Wang, Zifeng,Huang, Peng,Wen, Shijun. "Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma". . p. 10167 - 10184. Retrieved 2021/07/26.
• 4、 -. "LIGAND DRUG CONJUGATES AND MODIFIED BET INHIBITORS". Page/Page column 9-10. . Retrieved 2021/07/17.