1-BOC-5-AMINO-2,3-DIHYDRO-INDOLE

Base Information

• Chemical Name: 1-BOC-5-AMINO-2,3-DIHYDRO-INDOLE
• CAS No.: 129487-92-9
• Molecular Formula: C13H18 N2 O2
• Molecular Weight: 234.298
• Hs Code.: 2933990090
• Mol file: 129487-92-9.mol

Synonyms:5-Amino-2,3-dihydroindole-1-carboxylicacid tert-butyl ester; N-Boc-5-aminoindoline; tert-Butyl5-amino-1-indolinecarboxylate; tert-Butyl5-amino-2,3-dihydroindole-1-carboxylate

Chemical Property of 1-BOC-5-AMINO-2,3-DIHYDRO-INDOLE

Chemical Property:

• Boiling Point: 385.2±41.0 °C(Predicted)
• PKA: 5.44±0.20(Predicted)
• PSA: 55.56000
• Density: 1.177±0.06 g/cm3(Predicted)
• LogP: 3.21260
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl5-Amino-2,3-dihydro-1H-indole-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-5-AMINO-2,3-DIHYDRO-INDOLE

There total 6 articles about 1-BOC-5-AMINO-2,3-DIHYDRO-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 5-nitroindoline-1-carboxylate (129488-25-1) → tert-butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate (129487-92-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1.5h;

Reference yield: 100.0%

5-nitroindole-1-carboxylic acid tert-butyl ester (166104-19-4) → tert-butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate (129487-92-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1.5h;

Reference yield: 100.0%

→ tert-butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate (129487-92-9)

Guidance literature:

upstream raw materials:

5-nitroindole-1-carboxylic acid tert-butyl ester

tert-butyl 5-nitroindoline-1-carboxylate

di-tert-butyl dicarbonate

5-nitro-2,3-dihydro-1H-indole

Downstream raw materials:

C₁₄H₁₂Cl₂N₂O₂S

Refernces

• 1、 Chandrasekhar, Srivari,Basu, Debjit,Reddy, Ch. Raji. "Palladium-catalyzed reduction of N-(tert-Butoxycarbonyl)indoles by polymethylhydrosiloxane". . p. 1509 - 1512. Retrieved 2007.
• 2、 -. "LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS". Paragraph 0734. . Retrieved 2017/04/28.