BOC-D-CHA-OL

Base Information

• Chemical Name: BOC-D-CHA-OL
• CAS No.: 129593-17-5
• Molecular Formula: C14H27 N O3
• Molecular Weight: 257.373
• Mol file: 129593-17-5.mol

Synonyms:Carbamicacid, [(1R)-2-cyclohexyl-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethyl ester(9CI); Carbamic acid, [2-cyclohexyl-1-(hydroxymethyl)ethyl]-, 1,1-dimethylethylester, (R)-

Chemical Property of BOC-D-CHA-OL

Chemical Property:

• PSA: 58.56000
• LogP: 3.23330

Purity/Quality:

98%min ^*data from raw suppliers

D-Boc-cyclohexylalaninol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-CHA-OL

There total 3 articles about BOC-D-CHA-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-tert-butoxycarbonyl-D-Phenylalaninol (106454-69-7) → Boc-D-cyclohexylalaninol (129593-17-5)

Guidance literature:

With 5% rhodium-on-charcoal; hydrogen; In methanol; water; at 60 ℃; for 16h; under 2828.7 - 3087.28 Torr;

DOI:10.1021/op0200773

Reference yield:

sodium bis(2-methoxyethoxy)aluminum hydride (Red-Al) + N-tert-butoxycarbonyl-D-cyclohexylalanine (127095-92-5) → Boc-D-cyclohexylalaninol (129593-17-5)

Guidance literature:

In toluene;

Reference yield:

N-tert-butoxycarbonyl-D-cyclohexylalanine (127095-92-5) → Boc-D-cyclohexylalaninol (129593-17-5)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 0 - 25 ℃;

DOI:10.1016/j.bmcl.2003.12.031

upstream raw materials:

N-tert-butoxycarbonyl-D-cyclohexylalanine

N-tert-butoxycarbonyl-D-Phenylalaninol

Downstream raw materials:

D-Boc-cyclohexylalaninal

D-cyclohexylalaninol hydrochloride

C₂₂H₃₀N₂O₄

N-benzoyl-D-cyclohexylalaninol

Refernces

• 1、 -. "3-AMINO-2-HRYDROXYALKANOIC ACIDS AND THEIR PRODRUGS". Page 15. . Retrieved 2010/02/06.
• 2、 Ager, David J.,Prakash, Indra. "Reductions of aromatic amino acids and derivatives". . p. 164 - 167. Retrieved 2013/09/05.