Technology Process of 2-Azetidinone,1-amino-3-(1-hydroxyethyl)-,(R*,S*)-(9CI)
There total 7 articles about 2-Azetidinone,1-amino-3-(1-hydroxyethyl)-,(R*,S*)-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran; acetonitrile;
at 50 ℃;
DOI:10.1021/jo00311a023
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrazine hydrate / methanol / 4 h / Heating
2: Et3N, NaI / dimethylformamide / Ambient temperature
3: 2.59 g / imidazole / dimethylformamide / 24 h / Ambient temperature
4: 64 percent / 60percent NaH / tetrahydrofuran / 1) 0 deg C, 2) r.t.
5: 60 percent / ethanol / Irradiation; 1) Pyrex, 1.5 h, 2) Vycor, 1.5 h
6: 65 percent / tetra-n-butyl-ammonium fluoride / acetonitrile; tetrahydrofuran / 50 °C
7: tetra-n-butyl-ammonium fluoride / acetonitrile; tetrahydrofuran / 50 °C
With
1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; hydrazine hydrate; triethylamine; sodium iodide;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00311a023
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2.59 g / imidazole / dimethylformamide / 24 h / Ambient temperature
2: 64 percent / 60percent NaH / tetrahydrofuran / 1) 0 deg C, 2) r.t.
3: 60 percent / ethanol / Irradiation; 1) Pyrex, 1.5 h, 2) Vycor, 1.5 h
4: 65 percent / tetra-n-butyl-ammonium fluoride / acetonitrile; tetrahydrofuran / 50 °C
5: tetra-n-butyl-ammonium fluoride / acetonitrile; tetrahydrofuran / 50 °C
With
1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00311a023