6-Dimethoxyphosphonyl-5-oxohexanoic acid, min. 95 %

Base Information

• Chemical Name: 6-Dimethoxyphosphonyl-5-oxohexanoic acid, min. 95 %
• CAS No.: 130121-24-3
• Molecular Formula: C₈H₁₅O₆P
• Molecular Weight: 238.177
• Mol file: 130121-24-3.mol

Synonyms:6-Dimethoxyphosphonyl-5-oxohexanoic acid, min. 95 %

Chemical Property of 6-Dimethoxyphosphonyl-5-oxohexanoic acid, min. 95 %

Chemical Property:

• Boiling Point: 406.2±25.0 °C(Predicted)
• PKA: 4.59±0.10(Predicted)
• PSA: 99.71000
• Density: 1.258±0.06 g/cm3(Predicted)
• LogP: 1.29630

Purity/Quality:

97% ^*data from raw suppliers

6-DIMETHOXYPHOSPHONYL-5-OXOHEXANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Dimethoxyphosphonyl-5-oxohexanoic acid, min. 95 %

There total 4 articles about 6-Dimethoxyphosphonyl-5-oxohexanoic acid, min. 95 % which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimethyl 2-oxo-5-(carbo-tert-butoxy)pentanephosphonate (87517-46-2) → 6-(dimethoxyphosphonyl)-5-oxohexanoic acid (130121-24-3)

Guidance literature:

With trifluoroacetic acid; for 0.5h; Ambient temperature;

DOI:10.1021/jo00312a031

Reference yield:

glutaric anhydride, (108-55-4) + dimethyl methane phosphonate (756-79-6) → 6-(dimethoxyphosphonyl)-5-oxohexanoic acid (130121-24-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -80 ℃; for 0.5h; Cooling with ice; Inert atmosphere;

DOI:10.1016/j.tet.2015.10.003

Reference yield:

methyl 4-(chlorocarbonyl)butyrate (1501-26-4) → 6-(dimethoxyphosphonyl)-5-oxohexanoic acid (130121-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / pyridine / tetrahydrofuran / 1) -78 deg C, 2) warm to RT, 3) reflux, 10 h

2: 1) n-butyllithium / 1) hexane, THF, -78 deg C, 2a) THF, -78 deg C, 2 h, 2b) warm to RT

3: 95 percent / trifluororacetic acid / 0.5 h / Ambient temperature

With pyridine; n-butyllithium; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1021/jo00312a031

upstream raw materials:

dimethyl 2-oxo-5-(carbo-tert-butoxy)pentanephosphonate

methyl 4-(chlorocarbonyl)butyrate

5-tert-butyl methyl glutarate

glutaric anhydride,

Downstream raw materials:

(+/-)-LTB₃