4(1H)-Quinazolinone, 8-amino- (9CI)

Base Information

• Chemical Name: 4(1H)-Quinazolinone, 8-amino- (9CI)
• CAS No.: 130148-49-1
• Molecular Formula: C8H7 N3 O
• Molecular Weight: 161.16068
• Mol file: 130148-49-1.mol

Synonyms:4(1H)-Quinazolinone,8-amino- (9CI)

Chemical Property of 4(1H)-Quinazolinone, 8-amino- (9CI)

Chemical Property:

• PSA: 71.77000
• LogP: 1.08650

Purity/Quality:

NLT 98% ^*data from raw suppliers

8-Aminoquinazolin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(1H)-Quinazolinone, 8-amino- (9CI)

There total 2 articles about 4(1H)-Quinazolinone, 8-amino- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

8-nitroquinazoline-4(3H)-one (53638-54-3) → 8-aminoquinazolin-4(3H)-one (130148-49-1)

Guidance literature:

With stannous chloride dihydrate; In ethyl acetate; for 8h; Reflux;

DOI:10.1016/j.ejmech.2012.02.001

Reference yield:

3-nitroanthranilic acid (606-18-8) → 8-aminoquinazolin-4(3H)-one (130148-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 210 °C

2: Na₂S; water

With sodium sulfide; water;

DOI:10.1017/S0714980800000672

Reference yield: 51.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 8-aminoquinazolin-4(3H)-one (130148-49-1) → 8-<(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)amino>quinazolin-4(3H)-one (130148-57-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; potassium carbonate; In acetonitrile; at 25 ℃; for 8h;

DOI:10.1021/jo00002a052

upstream raw materials:

8-nitroquinazoline-4(3H)-one

3-nitroanthranilic acid

Downstream raw materials:

8-<(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)amino>quinazolin-4(3H)-one