4-Pyridinecarbonitrile,2,3-dimethyl-(9CI)

Base Information

• Chemical Name: 4-Pyridinecarbonitrile,2,3-dimethyl-(9CI)
• CAS No.: 131895-50-6
• Molecular Formula: C8H8 N2
• Molecular Weight: 132.16
• Mol file: 131895-50-6.mol

Synonyms:4-Pyridinecarbonitrile,2,3-dimethyl-(9CI)

Chemical Property of 4-Pyridinecarbonitrile,2,3-dimethyl-(9CI)

Chemical Property:

• PSA: 36.68000
• LogP: 1.57008

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dimethyl-4-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-Dimethyl-4-pyridinecarbonitrile is an intermediate used to prepare subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors. It is also used in the synthesis of pyridylmethylsulfonamides as fungicides.

Technology Process of 4-Pyridinecarbonitrile,2,3-dimethyl-(9CI)

There total 2 articles about 4-Pyridinecarbonitrile,2,3-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium cyanide → 4-cyano-2,3-dimethylpyridine (131895-50-6)

Guidance literature:

With dimethyl sulfate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

potassium cyanide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

2,3-dimethylpyridine 1-oxide (22710-07-2,166521-76-2) + potassium cyanide (151-50-8) → 4-cyano-2,3-dimethylpyridine (131895-50-6)

Guidance literature:

With dimethyl sulfate; Yield given. Multistep reaction; 1.) 14 h, r.t., 2.) 50percent aq. EtOH, 14 h, r.t.;

DOI:10.1002/jhet.5570270645

Reference yield: 28.0%

methyllithium (917-54-4) + 4-cyano-2,3-dimethylpyridine (131895-50-6) → 4-acetyl-2,3-dimethylpyridine (83402-07-7)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 14h; Ambient temperature;

DOI:10.1002/jhet.5570270645

upstream raw materials:

2,3-dimethylpyridine 1-oxide

potassium cyanide

Downstream raw materials:

4-acetyl-2,3-dimethylpyridine

Refernces

• 1、 Hibino,Sugino. "Synthesis of ellipticine and olivacine by the thermal electrocyclic reaction via pyridine 3,4-quinodimethane intermediates". . p. 1751 - 1755. Retrieved 2007/10/02.