4-Fluorophenylmagnesium chloride

Base Information

• Chemical Name: 4-Fluorophenylmagnesium chloride
• CAS No.: 130387-74-5
• Molecular Formula: C6H4 Cl F Mg
• Molecular Weight: 154.854
• Mol file: 130387-74-5.mol

Synonyms:Benzene,fluoro-, magnesium complex; (p-Fluorophenyl)magnesium chloride;4-Fluorophenylmagnesium chloride

Chemical Property of 4-Fluorophenylmagnesium chloride

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluorophenylmagnesium chloride

There total 1 articles about 4-Fluorophenylmagnesium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → 4-fluorophenylmagnesium chloride (130387-74-5)

Guidance literature:

at 20 ℃; for 3h;

Reference yield: 96.0%

triethylchlorogermane (994-28-5) + 4-fluorophenylmagnesium chloride (130387-74-5) → triethyl(4-fluorophenyl)germane

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.202005066

Reference yield: 95.0%

C9H8FIO (1334314-96-3) + 4-fluorophenylmagnesium chloride (130387-74-5) → 2-fluoro-4-(1-(4-fluorophenyl)vinyl)-1-methoxybenzene (1379793-81-3)

Guidance literature:

With iron(III) chloride; copper(I) thiophene-2-carboxylate; In tetrahydrofuran; at -20 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol3010112

upstream raw materials:

1-Bromo-4-fluorobenzene

Downstream raw materials:

4-(4-fluoro-benzyl)-1-methyl-piperidin-4-ol

1-ethyl-4-(4-fluoro-benzyl)-piperidin-4-ol

4-(4-fluoro-benzyl)-1-phenethyl-piperidin-4-ol

9-(4-fluorobenzyl)-9H-fluoren-9-ol

Refernces