Carbamic acid, (1-cyano-2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (1-cyano-2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 130457-35-1
• Molecular Formula: C₁₀H₁₈N₂O₂
• Molecular Weight: 198.265
• Mol file: 130457-35-1.mol

Synonyms:Carbamicacid, (1-cyano-2-methylpropyl)-, 1,1-dimethylethyl ester, (?à)-; tert-Butyl (1-cyanoisobutyl)carbamate

Chemical Property of Carbamic acid, (1-cyano-2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 62.12000
• LogP: 2.45018

Purity/Quality:

99.0%Min ^*data from raw suppliers

tert-ButylN-(1-cyano-2-methylpropyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (1-cyano-2-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

There total 6 articles about Carbamic acid, (1-cyano-2-methylpropyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

t-butyl (130457-26-0) → N-Boc-2-amino-3-methyl-butyronitrile (130457-35-1,142055-86-5)

Guidance literature:

With potassium cyanide; In dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield: 81.0%

potassium cyanide (151-50-8) + (1-benzenesulfonyl-2-methyl-propyl)-carbamic acid tert-butyl ester → N-Boc-2-amino-3-methyl-butyronitrile (130457-35-1,142055-86-5)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; at 20 ℃; for 3h;

DOI:10.1081/SCC-200028592

Reference yield: 80.0%

N-Boc-(S/R)-valine (13734-41-3,22838-58-0,54895-12-4) + 3-oxo-1λ3-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile (172876-96-9) → N-Boc-2-amino-3-methyl-butyronitrile (130457-35-1,142055-86-5)

Guidance literature:

With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; cesium benzoate; In tetrahydrofuran; at 20 ℃; Molecular sieve; Irradiation;

DOI:10.1039/c6sc04907a

upstream raw materials:

t-butyl

potassium cyanide

tert-butyl carbazate

P-toluenesulfonyl cyanide

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