Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1S-trans)- (9CI)

Base Information

• Chemical Name: Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1S-trans)- (9CI)
• CAS No.: 130888-10-7
• Molecular Formula: C₁₁H₉F₃O
• Molecular Weight: 214.187
• Mol file: 130888-10-7.mol

Synonyms:Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1S-trans)- (9CI)

Chemical Property of Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1S-trans)- (9CI)

Chemical Property:

• PSA: 17.07000
• LogP: 2.92150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1S-trans)- (9CI)

There total 2 articles about Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1S-trans)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2,2,2-Trifluoro-1-((1R,2S)-2-phenyl-cyclopropyl)-ethanol (128726-28-3,130979-92-9,130979-93-0,130979-94-1,130979-95-2,130980-03-9,130980-04-0,130980-05-1) → 2,2,2-Trifluoro-1-((1R,2S)-2-phenyl-cyclopropyl)-ethanone (130888-10-7,130980-00-6,130980-01-7)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; at -50 - 0 ℃;

DOI:10.1016/0957-4166(90)90031-5

Reference yield:

(Z)-(R)-1-phenyl-3-hydroxy-4,4,4-trifluoro-1-butene (108644-86-6) → 2,2,2-Trifluoro-1-((1R,2S)-2-phenyl-cyclopropyl)-ethanone (130888-10-7,130980-00-6,130980-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Sm / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 1 h

2: (COCl)2, Me₂SO, Et₃N / -50 - 0 °C

With samarium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran;

DOI:10.1016/0957-4166(90)90031-5

Reference yield:

2,2,2-Trifluoro-1-((1R,2S)-2-phenyl-cyclopropyl)-ethanone (130888-10-7,130980-00-6,130980-01-7) → (S)-2,2,2-Trifluoro-1-((1S,2R)-2-phenyl-cyclopropyl)-ethanol (130980-05-1)

Guidance literature:

With L-Selectride; In ethanol; Yield given;

DOI:10.1016/0957-4166(90)90031-5

upstream raw materials:

(R)-2,2,2-Trifluoro-1-((1R,2S)-2-phenyl-cyclopropyl)-ethanol

(Z)-(R)-1-phenyl-3-hydroxy-4,4,4-trifluoro-1-butene

Downstream raw materials:

(S)-2,2,2-Trifluoro-1-((1S,2R)-2-phenyl-cyclopropyl)-ethanol