Imidazo[4,5-d][1,3]oxazin-7(1H)-one, 5-amino- (9CI)

Base Information

• Chemical Name: Imidazo[4,5-d][1,3]oxazin-7(1H)-one, 5-amino- (9CI)
• CAS No.: 130890-45-8
• Molecular Formula: C₅H₄N₄O₂
• Molecular Weight: 152.112
• Mol file: 130890-45-8.mol

Synonyms:Imidazo[4,5-d][1,3]oxazin-7(1H)-one,5-amino- (9CI); Oxanine

Chemical Property of Imidazo[4,5-d][1,3]oxazin-7(1H)-one, 5-amino- (9CI)

Chemical Property:

• PSA: 97.80000
• LogP: 0.07450

Purity/Quality:

99% ^*data from raw suppliers

5-amino-Imidazo[4,5-d][1,3]oxazin-7(3H)-one 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[4,5-d][1,3]oxazin-7(1H)-one, 5-amino- (9CI)

There total 3 articles about Imidazo[4,5-d][1,3]oxazin-7(1H)-one, 5-amino- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

C11H16N4O4S → xanthine (130890-45-8)

Guidance literature:

With sodium hydroxide; at 95 - 100 ℃;

DOI:10.1002/jhet.5570270525

Reference yield:

2'-Deoxyguanosine (961-07-9) → 2'-deoxyxanthosine (29049-22-7,25843-96-3) + xanthine (130890-45-8) + 2'-deoxyoxanosine (88899-00-7) + 2-nitro-2'-deoxyinosine

Guidance literature:

With acetate buffer; sodium nitrite; at 37 ℃; for 6h; Yield given. Yields of byproduct given;

DOI:10.1021/ja952550g

Reference yield:

5-(N'-Ethoxycarbonylthiocarbamoyl)amino-4-ethoxycarbonylimidazole (130890-47-0) → xanthine (130890-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / 1N NaOH / methanol / ice-water

2: 8 percent / 6N NaOH / 95 - 100 °C

With sodium hydroxide; In methanol;

DOI:10.1002/jhet.5570270525

upstream raw materials:

2'-Deoxyguanosine

5-(N'-Ethoxycarbonylthiocarbamoyl)amino-4-ethoxycarbonylimidazole