Cyclobutanecarboxaldehyde, 2-(1-methoxyethyl)-, [1alpha,2alpha(R*)]- (9CI)

Base Information

• Chemical Name: Cyclobutanecarboxaldehyde, 2-(1-methoxyethyl)-, [1alpha,2alpha(R*)]- (9CI)
• CAS No.: 133868-22-1
• Molecular Formula: C8H14O2
• Molecular Weight: 142.19556
• Mol file: 133868-22-1.mol

Synonyms:Cyclobutanecarboxaldehyde, 2-(1-methoxyethyl)-, [1alpha,2alpha(R*)]- (9CI)

Chemical Property of Cyclobutanecarboxaldehyde, 2-(1-methoxyethyl)-, [1alpha,2alpha(R*)]- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclobutanecarboxaldehyde, 2-(1-methoxyethyl)-, [1alpha,2alpha(R*)]- (9CI)

There total 7 articles about Cyclobutanecarboxaldehyde, 2-(1-methoxyethyl)-, [1alpha,2alpha(R*)]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1RS,2RS,1'SR)-1-(1-methoxyethyl)-2-vinylcyclobutane (125109-47-9,125224-60-4,133815-35-7,133815-36-8,133868-06-1,133868-12-9,133868-33-4) → 3,5-Bis-[(1R,2S)-2-((R)-1-methoxy-ethyl)-cyclobutyl]-[1,2,4]trioxolane + (1SR,2RS,1'SR)-2-(1-methoxyethyl)cyclobutanecarboxaldehyde (133796-83-5,133868-13-0,133868-22-1,133868-23-2,133868-31-2)

Guidance literature:

With ozone; In dichloromethane; at -78 ℃;

DOI:10.1021/ja00012a033

Reference yield:

(1SR,1'RS,2'RS)-1-(2-vinylcyclobutyl)ethanol (125109-46-8,125224-59-1,133868-19-6,133868-20-9,133868-34-5) → (1SR,2RS,1'SR)-2-(1-methoxyethyl)cyclobutanecarboxaldehyde (133796-83-5,133868-13-0,133868-22-1,133868-23-2,133868-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82.3 percent / NaH / tetrahydrofuran / 2.5 h / Ambient temperature

2: O₃ / CH₂Cl₂ / -78 °C

With sodium hydride; ozone; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00012a033

Reference yield:

4-Methyl-3-oxa-bicyclo[3.2.0]heptan-2-ol (125137-90-8) → (1SR,2RS,1'SR)-2-(1-methoxyethyl)cyclobutanecarboxaldehyde (133796-83-5,133868-13-0,133868-22-1,133868-23-2,133868-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 37.1 percent / tetrahydrofuran / 4.5 h / Ambient temperature

2: 82.3 percent / NaH / tetrahydrofuran / 2.5 h / Ambient temperature

3: O₃ / CH₂Cl₂ / -78 °C

With sodium hydride; ozone; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00012a033

upstream raw materials:

(1RS,2RS,1'RS)-1-(1-methoxyethyl)-2-vinylcyclobutane

(1SR,1'SR,2'SR)-1-(2-vinylcyclobutyl)ethanol

4-Methyl-3-oxa-bicyclo[3.2.0]heptan-2-ol

(1RS,2RS,1'SR)-1-(1-methoxyethyl)-2-vinylcyclobutane